Biochemistry and molecular cell biology of diabetic complications

M. Brownlee

Research output: Contribution to journalArticle

5855 Citations (Scopus)

Abstract

Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.

Original languageEnglish (US)
Pages (from-to)813-820
Number of pages8
JournalNature
Volume414
Issue number6865
DOIs
StatePublished - Dec 13 2001

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Diabetes Complications
Drug Discovery
Blindness
Electron Transport
Amputation
Superoxides
Hyperglycemia
Biochemistry
Renal Insufficiency
Blood Vessels
Cell Biology
Molecular Biology
Atherosclerosis
Extremities
Stroke
Myocardial Infarction
Glucose

ASJC Scopus subject areas

  • General

Cite this

Biochemistry and molecular cell biology of diabetic complications. / Brownlee, M.

In: Nature, Vol. 414, No. 6865, 13.12.2001, p. 813-820.

Research output: Contribution to journalArticle

Brownlee, M. / Biochemistry and molecular cell biology of diabetic complications. In: Nature. 2001 ; Vol. 414, No. 6865. pp. 813-820.
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