Binding and cross-linking properties of galectins

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148 Citations (Scopus)

Abstract

The galectins are a family of animal lectins that possess similar carbohydrate binding specificities and conserved consensus sequences. The biological properties of mammalian galectins include the regulation of inflammation, cell adhesion, cell proliferation and cell death. Evidence suggests that the biological activities of the galectins are related to their multivalent binding properties since most galectins possess two carbohydrate recognition domains and are therefore bivalent. For example, galectin-1, which is dimeric, binds and cross-links specific glycoprotein counter-receptors on the surface of human T-cells leading to apoptosis [J. Immunol. 163 (1999) 3801]. Different galectin-1 counter-receptors associated with specific phosphatase or kinase activities formed separate clusters on the surface of the cells as a result of the lectin binding to the carbohydrate chains of the respective glycoproteins. Importantly, monovalent galectin-1 is inactive in this system. This indicates that the separation and organization of signaling molecules that result from galectin-1 binding is involved in the apoptotic signal. The separation of specific glycoprotein receptors induced by galectin-1 binding was modeled on the basis of molecular and structural studies of the binding of lectins to multivalent carbohydrates resulting in the formation of specific two- and three-dimensional cross-linked lattices [Biochemistry 36 (1997) 15073]. In this article, the binding and cross-linking properties of galectin-1 and other lectins are reviewed as a model for the biological signal transduction properties of the galectin family of animal lectins.

Original languageEnglish (US)
Pages (from-to)255-262
Number of pages8
JournalBiochimica et Biophysica Acta - General Subjects
Volume1572
Issue number2-3
DOIs
StatePublished - Sep 19 2002

Fingerprint

Galectin 1
Galectins
Lectins
Carbohydrates
Glycoproteins
Biological Models
Signal transduction
Biochemistry
T-cells
Conserved Sequence
Cell adhesion
Consensus Sequence
Cell proliferation
Cell death
Bioactivity
Phosphoric Monoester Hydrolases
Cell Adhesion
Signal Transduction
Cell Death
Phosphotransferases

Keywords

  • Cross-linking
  • Galectin
  • Lattice
  • Signal transduction

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Binding and cross-linking properties of galectins. / Brewer, Curtis F.

In: Biochimica et Biophysica Acta - General Subjects, Vol. 1572, No. 2-3, 19.09.2002, p. 255-262.

Research output: Contribution to journalArticle

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