Binaural gain modulation of spectrotemporal tuning in the interaural level difference-coding pathway

Louisa J. Steinberg, Brian J. Fischer, Jose L. Pena

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In the brainstem, the auditory system diverges into two pathways that process different sound localization cues, interaural time differences (ITDs) and level differences (ILDs).Weinvestigated the site where ILD is detected in the auditory system of barn owls, the posterior part of the lateral lemniscus (LLDp). This structure is equivalent to the lateral superior olive in mammals. The LLDp is unique in that it is the first place of binaural convergence in the brainstem where monaural excitatory and inhibitory inputs converge. Using binaurally uncorrelated noise and a generalized linear model, we were able to estimate the spectrotemporal tuning of excitatory and inhibitory inputs to these cells. We show that the response of LLDp neurons is highly locked to the stimulus envelope. Our data demonstrate that spectrotemporally tuned, temporally delayed inhibition enhances the reliability of envelope locking by modulating the gain of LLDp neurons' responses. The dependence of gain modulation on ILD shown here constitutes a means for space-dependent coding of stimulus identity by the initial stages of the auditory pathway.

Original languageEnglish (US)
Pages (from-to)11089-11099
Number of pages11
JournalJournal of Neuroscience
Volume33
Issue number27
DOIs
StatePublished - 2013

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Brain Stem
Strigiformes
Sound Localization
Auditory Pathways
Neurons
Cues
Noise
Mammals
Linear Models
Inhibition (Psychology)
Superior Olivary Complex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Binaural gain modulation of spectrotemporal tuning in the interaural level difference-coding pathway. / Steinberg, Louisa J.; Fischer, Brian J.; Pena, Jose L.

In: Journal of Neuroscience, Vol. 33, No. 27, 2013, p. 11089-11099.

Research output: Contribution to journalArticle

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