Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1

Judit Hargitai, Hannah Lewis, Imre Boros, Tímea Rácz, Andras Fiser, István Kurucz, Ivor Benjamin, László Vígh, Zoltán Pénzes, Péter Csermely, David S. Latchman

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

The novel hydroxylamine derivative, bimoclomol, has been shown previously to act as a co-inducer of several heat shock proteins (Hsp-s), enhancing the amount of these proteins produced following a heat shock compared to heat shock alone. Here we show that the co-inducing effect of bimoclomol on Hsp expression is mediated via the prolonged activation of the heat shock transcription factor (HSF-1). Bimoclomol effects are abolished in cells from mice lacking HSF-1. Moreover, bimoclomol binds to HSF-1 and induces a prolonged binding of HSF-1 to the respective DNA elements. Since HSF-1 does not bind to DNA in the absence of stress, the bimoclomol-induced extension of HSF-1/DNA interaction may contribute to the chaperone co-induction of bimoclomol observed previously. These findings indicate that bimoclomol may be of value in targeting HSF-1 so as to induce up-regulation of protective Hsp-s in a non-stressful manner and for therapeutic benefit.

Original languageEnglish (US)
Pages (from-to)689-695
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume307
Issue number3
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

Fingerprint

Heat-Shock Proteins
Shock
Hot Temperature
Chemical activation
DNA
Hydroxylamine
bimoclomol
Up-Regulation
Derivatives
Proteins

Keywords

  • Bimoclomol
  • Chaperones
  • HSF-1
  • Hsp47
  • Hsp70
  • Hsp90

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1. / Hargitai, Judit; Lewis, Hannah; Boros, Imre; Rácz, Tímea; Fiser, Andras; Kurucz, István; Benjamin, Ivor; Vígh, László; Pénzes, Zoltán; Csermely, Péter; Latchman, David S.

In: Biochemical and Biophysical Research Communications, Vol. 307, No. 3, 01.08.2003, p. 689-695.

Research output: Contribution to journalArticle

Hargitai, J, Lewis, H, Boros, I, Rácz, T, Fiser, A, Kurucz, I, Benjamin, I, Vígh, L, Pénzes, Z, Csermely, P & Latchman, DS 2003, 'Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1', Biochemical and Biophysical Research Communications, vol. 307, no. 3, pp. 689-695. https://doi.org/10.1016/S0006-291X(03)01254-3
Hargitai, Judit ; Lewis, Hannah ; Boros, Imre ; Rácz, Tímea ; Fiser, Andras ; Kurucz, István ; Benjamin, Ivor ; Vígh, László ; Pénzes, Zoltán ; Csermely, Péter ; Latchman, David S. / Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1. In: Biochemical and Biophysical Research Communications. 2003 ; Vol. 307, No. 3. pp. 689-695.
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