Bilirubin metabolism

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bilirubin, a degradation product of heme, is produced largely by metabolism of hemoglobin released from senescent red blood cells. Other sources of bilirubin include turnover of heme-containing proteins such as cytochromes, hemolytic disorders, and ineffective erythropoiesis as seen in thalassemias. Bilirubin has been an object of study for many years, but it is probably its yellow color rather than its physiologic importance that has driven these investigations. Under rare circumstances, especially in premature babies with hyperbilirubinemia, bilirubin can cross the blood-brain barrier and cause kernicterus, a neurologic syndrome that may result in severe developmental deficits and death. Recent studies suggest that in normal adults bilirubin may have some role as an antioxidant. This chapter reviews the subjects of bilirubin metabolism and transport.

Original languageEnglish (US)
Title of host publicationGastrointestinal Anatomy and Physiology
Subtitle of host publicationThe Essentials
PublisherWiley-Blackwell
Pages173-182
Number of pages10
ISBN (Electronic)9781118833001
ISBN (Print)9780470674840
DOIs
StatePublished - May 5 2014

Keywords

  • Bilirubin
  • Crigler-Najjar syndrome
  • Dubin-Johnson syndrome
  • Gilbert syndrome
  • Glucuronic acid
  • Hemolysis
  • Rotor syndrome

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Wolkoff, A. W. (2014). Bilirubin metabolism. In Gastrointestinal Anatomy and Physiology: The Essentials (pp. 173-182). Wiley-Blackwell. https://doi.org/10.1002/9781118833001.ch12