Bile salts. Their role in cholesterol synthesis, secretion and lithogenesis

Lawrence J. Brandt, L. H. Bernstein

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Many intriguing new concepts have emerged regarding the contributory role of bile salts in health and disease. This review is concerned with the physicochemical properties of bile salts and the regulatory effects of bile salts on their own hepatic synthesis and on the hepatic and intestinal synthesis of cholesterol. The quantitative aspects of bile salt secretion and recycling in the enterohepatic circulation are discussed with particular reference to the genesis of cholesterol gallstone disease. Although the terms bile salt and bile acid are used interchangeably by some authors, all physiological functions are performed in the salt (amino acid conjugate) form. Thus when not specifically referring to the chemical pathways of their synthesis, the term bile salt is used in this review in discussing synthesis and secretion of cholesterol and pathogenetic aspects of gallstone formation.

Original languageEnglish (US)
Pages (from-to)17-30
Number of pages14
JournalAmerican Journal of Gastroenterology
Volume65
Issue number1
StatePublished - 1976
Externally publishedYes

Fingerprint

Bile Acids and Salts
Cholesterol
Gallstones
Enterohepatic Circulation
Liver
Recycling
Salts
Amino Acids
Health

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Bile salts. Their role in cholesterol synthesis, secretion and lithogenesis. / Brandt, Lawrence J.; Bernstein, L. H.

In: American Journal of Gastroenterology, Vol. 65, No. 1, 1976, p. 17-30.

Research output: Contribution to journalArticle

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