Bile salts: Natural detergents for the prevention of sexually transmitted diseases

Betsy C. Herold, Risa Kirkpatrick, Daniel Marcellino, Anna Travelstead, Valentina Pilipenko, Holly Krasa, James Bremer, Li Jin Dong, Morris D. Cooper

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

The development of new, safe, topical microbicides for intravaginal use for the prevention of sexually transmitted diseases is imperative. Previous studies have suggested that bile salts may inhibit human immunodeficiency virus infection; however, their activities against other sexually transmitted pathogens have not been reported. To further explore the potential role of bile salts in preventing sexually transmitted diseases, we examined the in vitro activities and cytotoxicities of select bile salts against Chlamydia trachomatis, herpes simplex virus (types 1 and 2), Neisseria gonorrhoeae, and human immunodeficiency virus in comparison to those of nonoxynol-9 and benzalkonium chloride using both primary cells and cell lines derived from the human female genital tract. We found that taurolithocholic acid 3- sulfate and a combination of glycocholic acid and taurolithocholic acid 3- sulfate showed excellent activity against all of the pathogens assayed. Moreover, taurolithocholic acid 3-sulfate alone or in combination was less cytotoxic than nonoxynol-9 and benzalkonium chloride. Thus, taurolithocholic acid 3-sulfate alone or in combination warrants further evaluation as a candidate topical microbicidal agent.

Original languageEnglish (US)
Pages (from-to)745-751
Number of pages7
JournalAntimicrobial Agents and Chemotherapy
Volume43
Issue number4
StatePublished - Apr 1999

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Herold, B. C., Kirkpatrick, R., Marcellino, D., Travelstead, A., Pilipenko, V., Krasa, H., Bremer, J., Dong, L. J., & Cooper, M. D. (1999). Bile salts: Natural detergents for the prevention of sexually transmitted diseases. Antimicrobial Agents and Chemotherapy, 43(4), 745-751.