Bile acid regulation of hepatic physiology I. Hepatocyte transport of bile acids

Allan W. Wolkoff, David E. Cohen

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Bile acids are cholesterol derivatives that serve as detergents in bile and the small intestine. Approximately 95% of bile acids secreted by hepatocytes into bile are absorbed from the distal ileum into the portal venous system. Extraction from the portal circulation by the hepatocyte followed by reexcretion into the bile canaliculus completes the enterohepatic circulation of these compounds. Over the past few years, candidate bile acid transport proteins of the sinusoidal and canalicular plasma membranes of the hepatocyte have been identified. The physiology of hepatocyte bile acid transport and its relationship to these transport proteins is the subject of this Themes article.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume284
Issue number2 47-2
StatePublished - Feb 1 2003

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Bile Acids and Salts
Hepatocytes
Liver
Bile
Carrier Proteins
Bile Canaliculi
Enterohepatic Circulation
Portal System
Ileum
Detergents
Small Intestine
Cholesterol
Cell Membrane

Keywords

  • Bile salt export pump
  • Na-taurocholate cotransporting polypeptide
  • Organic anion transporting protein

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Bile acid regulation of hepatic physiology I. Hepatocyte transport of bile acids. / Wolkoff, Allan W.; Cohen, David E.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 284, No. 2 47-2, 01.02.2003.

Research output: Contribution to journalArticle

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