Bile acid physiology

Agostino Di Ciaula, Gabriella Garruti, Raquel Lunardi Baccetto, Emilio Molina-Molina, Leonilde Bonfrate, David Q.H. Wang, Piero Portincasa

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The primary bile acids (BAs) are synthetized from cholesterol in the liver, conjugated to glycine or taurine to increase their solubility, secreted into bile, concentrated in the gallbladder during fasting, and expelled in the intestine in response to dietary fat. BAs are also bio-transformed in the colon to the secondary BAs by the gut microbiota, reabsorbed in the ileum and colon back to the liver, and minimally lost in the feces. BAs in the intestine not only regulate the digestion and absorption of cholesterol, triglycerides, and fatsoluble vitamins, but also play a key role as signaling molecules in modulating epithelial cell proliferation, gene expression, and lipid and glucose metabolismby activating farnesoid X receptor (FXR) and G-protein-coupled bile acid receptor-1 (GPBAR-1, also known as TGR5) in the liver, intestine, muscle and brown adipose tissue. Recent studies have revealed the metabolic pathways of FXR and GPBAR-1 involved in the biosynthesis and enterohepatic circulation of BAs and their functions as signaling molecules on lipid and glucose metabolism.

Original languageEnglish (US)
Pages (from-to)s4-s14
JournalAnnals of Hepatology
Volume16
DOIs
StatePublished - Nov 1 2017

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Bile Acids and Salts
Intestines
Liver
Colon
Cholesterol
Enterohepatic Circulation
Glucose
Brown Adipose Tissue
Dietary Fats
Taurine
G-Protein-Coupled Receptors
Metabolic Networks and Pathways
Gallbladder
Ileum
Lipid Metabolism
Feces
Bile
Vitamins
Solubility
Glycine

Keywords

  • Bile
  • Bile acids
  • FXR
  • Microbiota

ASJC Scopus subject areas

  • Hepatology

Cite this

Di Ciaula, A., Garruti, G., Baccetto, R. L., Molina-Molina, E., Bonfrate, L., Wang, D. Q. H., & Portincasa, P. (2017). Bile acid physiology. Annals of Hepatology, 16, s4-s14. https://doi.org/10.5604/01.3001.0010.5493

Bile acid physiology. / Di Ciaula, Agostino; Garruti, Gabriella; Baccetto, Raquel Lunardi; Molina-Molina, Emilio; Bonfrate, Leonilde; Wang, David Q.H.; Portincasa, Piero.

In: Annals of Hepatology, Vol. 16, 01.11.2017, p. s4-s14.

Research output: Contribution to journalArticle

Di Ciaula, A, Garruti, G, Baccetto, RL, Molina-Molina, E, Bonfrate, L, Wang, DQH & Portincasa, P 2017, 'Bile acid physiology', Annals of Hepatology, vol. 16, pp. s4-s14. https://doi.org/10.5604/01.3001.0010.5493
Di Ciaula A, Garruti G, Baccetto RL, Molina-Molina E, Bonfrate L, Wang DQH et al. Bile acid physiology. Annals of Hepatology. 2017 Nov 1;16:s4-s14. https://doi.org/10.5604/01.3001.0010.5493
Di Ciaula, Agostino ; Garruti, Gabriella ; Baccetto, Raquel Lunardi ; Molina-Molina, Emilio ; Bonfrate, Leonilde ; Wang, David Q.H. ; Portincasa, Piero. / Bile acid physiology. In: Annals of Hepatology. 2017 ; Vol. 16. pp. s4-s14.
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