Bile acid physiology

Agostino Di Ciaula, Gabriella Garruti, Raquel Lunardi Baccetto, Emilio Molina-Molina, Leonilde Bonfrate, David Q.H. Wang, Piero Portincasa

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The primary bile acids (BAs) are synthetized from cholesterol in the liver, conjugated to glycine or taurine to increase their solubility, secreted into bile, concentrated in the gallbladder during fasting, and expelled in the intestine in response to dietary fat. BAs are also bio-transformed in the colon to the secondary BAs by the gut microbiota, reabsorbed in the ileum and colon back to the liver, and minimally lost in the feces. BAs in the intestine not only regulate the digestion and absorption of cholesterol, triglycerides, and fatsoluble vitamins, but also play a key role as signaling molecules in modulating epithelial cell proliferation, gene expression, and lipid and glucose metabolismby activating farnesoid X receptor (FXR) and G-protein-coupled bile acid receptor-1 (GPBAR-1, also known as TGR5) in the liver, intestine, muscle and brown adipose tissue. Recent studies have revealed the metabolic pathways of FXR and GPBAR-1 involved in the biosynthesis and enterohepatic circulation of BAs and their functions as signaling molecules on lipid and glucose metabolism.

Original languageEnglish (US)
Pages (from-to)s4-s14
JournalAnnals of Hepatology
Volume16
DOIs
StatePublished - Nov 2017

Keywords

  • Bile
  • Bile acids
  • FXR
  • Microbiota

ASJC Scopus subject areas

  • Hepatology

Fingerprint Dive into the research topics of 'Bile acid physiology'. Together they form a unique fingerprint.

  • Cite this

    Di Ciaula, A., Garruti, G., Baccetto, R. L., Molina-Molina, E., Bonfrate, L., Wang, D. Q. H., & Portincasa, P. (2017). Bile acid physiology. Annals of Hepatology, 16, s4-s14. https://doi.org/10.5604/01.3001.0010.5493