Biceps detachment decreases joint damage in a rotator cuff tear rat model

Stephen J. Thomas, Katherine E. Reuther, Jennica J. Tucker, Joseph J. Sarver, Sarah M. Yannascoli, Adam C. Caro, Pramod B. Voleti, Sarah I. Rooney, David L. Glaser, Louis J. Soslowsky

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Pathology in the long head of the biceps tendon often occurs in patients with rotator cuff tears. Arthroscopic tenotomy is the most common treatment. However, the role of the long head of the biceps at the shoulder and the consequences of surgical detachment on the remaining shoulder structures remain unknown. Questions/purposes: We hypothesized that detachment of the long head of the biceps, in the presence of supraspinatus and infraspinatus tears, would decrease shoulder function and decrease mechanical and histologic properties of both the subscapularis tendon and the glenoid articular cartilage. Methods: We detached the supraspinatus and infraspinatus or the supraspinatus, infraspinatus, and long head of the biceps after 4 weeks of overuse in a rat model. Animals were gradually returned to overuse activity after detachment. At 8 weeks, the subscapularis and glenoid cartilage biomechanical and histologic properties were evaluated and compared. Results: The group with the supraspinatus, infraspinatus, and long head of the biceps detached had greater medial force and decreased change in propulsion, braking, and vertical force. This group also had an increased upper and lower subscapularis modulus but without any differences in glenoid cartilage modulus. Finally, this group had a significantly lower cell density in both the upper and lower subscapularis tendons, although cartilage histology was not different. Conclusions: Detachment of the long head of the biceps tendon in the presence of a posterior-superior cuff tear resulted in improved shoulder function and less joint damage in this animal model. Clinical Relevance: This study provides evidence in an animal model that supports the use of tenotomy for the management of long head of the biceps pathology in the presence of a two-tendon cuff tear. However, long-term clinical trials are required.

Original languageEnglish (US)
Pages (from-to)2404-2412
Number of pages9
JournalClinical Orthopaedics and Related Research
Volume472
Issue number8
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Rotator Cuff
Joints
Tendons
Tenotomy
Cartilage
Tears
Rotator Cuff Injuries
Animal Models
Pathology
Articular Cartilage
Histology
Cell Count
Clinical Trials

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Thomas, S. J., Reuther, K. E., Tucker, J. J., Sarver, J. J., Yannascoli, S. M., Caro, A. C., ... Soslowsky, L. J. (2014). Biceps detachment decreases joint damage in a rotator cuff tear rat model. Clinical Orthopaedics and Related Research, 472(8), 2404-2412. https://doi.org/10.1007/s11999-013-3422-8

Biceps detachment decreases joint damage in a rotator cuff tear rat model. / Thomas, Stephen J.; Reuther, Katherine E.; Tucker, Jennica J.; Sarver, Joseph J.; Yannascoli, Sarah M.; Caro, Adam C.; Voleti, Pramod B.; Rooney, Sarah I.; Glaser, David L.; Soslowsky, Louis J.

In: Clinical Orthopaedics and Related Research, Vol. 472, No. 8, 2014, p. 2404-2412.

Research output: Contribution to journalArticle

Thomas, SJ, Reuther, KE, Tucker, JJ, Sarver, JJ, Yannascoli, SM, Caro, AC, Voleti, PB, Rooney, SI, Glaser, DL & Soslowsky, LJ 2014, 'Biceps detachment decreases joint damage in a rotator cuff tear rat model', Clinical Orthopaedics and Related Research, vol. 472, no. 8, pp. 2404-2412. https://doi.org/10.1007/s11999-013-3422-8
Thomas, Stephen J. ; Reuther, Katherine E. ; Tucker, Jennica J. ; Sarver, Joseph J. ; Yannascoli, Sarah M. ; Caro, Adam C. ; Voleti, Pramod B. ; Rooney, Sarah I. ; Glaser, David L. ; Soslowsky, Louis J. / Biceps detachment decreases joint damage in a rotator cuff tear rat model. In: Clinical Orthopaedics and Related Research. 2014 ; Vol. 472, No. 8. pp. 2404-2412.
@article{1a78965edd9b4af1af328c15965f7060,
title = "Biceps detachment decreases joint damage in a rotator cuff tear rat model",
abstract = "Background: Pathology in the long head of the biceps tendon often occurs in patients with rotator cuff tears. Arthroscopic tenotomy is the most common treatment. However, the role of the long head of the biceps at the shoulder and the consequences of surgical detachment on the remaining shoulder structures remain unknown. Questions/purposes: We hypothesized that detachment of the long head of the biceps, in the presence of supraspinatus and infraspinatus tears, would decrease shoulder function and decrease mechanical and histologic properties of both the subscapularis tendon and the glenoid articular cartilage. Methods: We detached the supraspinatus and infraspinatus or the supraspinatus, infraspinatus, and long head of the biceps after 4 weeks of overuse in a rat model. Animals were gradually returned to overuse activity after detachment. At 8 weeks, the subscapularis and glenoid cartilage biomechanical and histologic properties were evaluated and compared. Results: The group with the supraspinatus, infraspinatus, and long head of the biceps detached had greater medial force and decreased change in propulsion, braking, and vertical force. This group also had an increased upper and lower subscapularis modulus but without any differences in glenoid cartilage modulus. Finally, this group had a significantly lower cell density in both the upper and lower subscapularis tendons, although cartilage histology was not different. Conclusions: Detachment of the long head of the biceps tendon in the presence of a posterior-superior cuff tear resulted in improved shoulder function and less joint damage in this animal model. Clinical Relevance: This study provides evidence in an animal model that supports the use of tenotomy for the management of long head of the biceps pathology in the presence of a two-tendon cuff tear. However, long-term clinical trials are required.",
author = "Thomas, {Stephen J.} and Reuther, {Katherine E.} and Tucker, {Jennica J.} and Sarver, {Joseph J.} and Yannascoli, {Sarah M.} and Caro, {Adam C.} and Voleti, {Pramod B.} and Rooney, {Sarah I.} and Glaser, {David L.} and Soslowsky, {Louis J.}",
year = "2014",
doi = "10.1007/s11999-013-3422-8",
language = "English (US)",
volume = "472",
pages = "2404--2412",
journal = "Clinical Orthopaedics and Related Research",
issn = "0009-921X",
publisher = "Springer New York",
number = "8",

}

TY - JOUR

T1 - Biceps detachment decreases joint damage in a rotator cuff tear rat model

AU - Thomas, Stephen J.

AU - Reuther, Katherine E.

AU - Tucker, Jennica J.

AU - Sarver, Joseph J.

AU - Yannascoli, Sarah M.

AU - Caro, Adam C.

AU - Voleti, Pramod B.

AU - Rooney, Sarah I.

AU - Glaser, David L.

AU - Soslowsky, Louis J.

PY - 2014

Y1 - 2014

N2 - Background: Pathology in the long head of the biceps tendon often occurs in patients with rotator cuff tears. Arthroscopic tenotomy is the most common treatment. However, the role of the long head of the biceps at the shoulder and the consequences of surgical detachment on the remaining shoulder structures remain unknown. Questions/purposes: We hypothesized that detachment of the long head of the biceps, in the presence of supraspinatus and infraspinatus tears, would decrease shoulder function and decrease mechanical and histologic properties of both the subscapularis tendon and the glenoid articular cartilage. Methods: We detached the supraspinatus and infraspinatus or the supraspinatus, infraspinatus, and long head of the biceps after 4 weeks of overuse in a rat model. Animals were gradually returned to overuse activity after detachment. At 8 weeks, the subscapularis and glenoid cartilage biomechanical and histologic properties were evaluated and compared. Results: The group with the supraspinatus, infraspinatus, and long head of the biceps detached had greater medial force and decreased change in propulsion, braking, and vertical force. This group also had an increased upper and lower subscapularis modulus but without any differences in glenoid cartilage modulus. Finally, this group had a significantly lower cell density in both the upper and lower subscapularis tendons, although cartilage histology was not different. Conclusions: Detachment of the long head of the biceps tendon in the presence of a posterior-superior cuff tear resulted in improved shoulder function and less joint damage in this animal model. Clinical Relevance: This study provides evidence in an animal model that supports the use of tenotomy for the management of long head of the biceps pathology in the presence of a two-tendon cuff tear. However, long-term clinical trials are required.

AB - Background: Pathology in the long head of the biceps tendon often occurs in patients with rotator cuff tears. Arthroscopic tenotomy is the most common treatment. However, the role of the long head of the biceps at the shoulder and the consequences of surgical detachment on the remaining shoulder structures remain unknown. Questions/purposes: We hypothesized that detachment of the long head of the biceps, in the presence of supraspinatus and infraspinatus tears, would decrease shoulder function and decrease mechanical and histologic properties of both the subscapularis tendon and the glenoid articular cartilage. Methods: We detached the supraspinatus and infraspinatus or the supraspinatus, infraspinatus, and long head of the biceps after 4 weeks of overuse in a rat model. Animals were gradually returned to overuse activity after detachment. At 8 weeks, the subscapularis and glenoid cartilage biomechanical and histologic properties were evaluated and compared. Results: The group with the supraspinatus, infraspinatus, and long head of the biceps detached had greater medial force and decreased change in propulsion, braking, and vertical force. This group also had an increased upper and lower subscapularis modulus but without any differences in glenoid cartilage modulus. Finally, this group had a significantly lower cell density in both the upper and lower subscapularis tendons, although cartilage histology was not different. Conclusions: Detachment of the long head of the biceps tendon in the presence of a posterior-superior cuff tear resulted in improved shoulder function and less joint damage in this animal model. Clinical Relevance: This study provides evidence in an animal model that supports the use of tenotomy for the management of long head of the biceps pathology in the presence of a two-tendon cuff tear. However, long-term clinical trials are required.

UR - http://www.scopus.com/inward/record.url?scp=84904121098&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904121098&partnerID=8YFLogxK

U2 - 10.1007/s11999-013-3422-8

DO - 10.1007/s11999-013-3422-8

M3 - Article

VL - 472

SP - 2404

EP - 2412

JO - Clinical Orthopaedics and Related Research

JF - Clinical Orthopaedics and Related Research

SN - 0009-921X

IS - 8

ER -