Beyond Mitophagy: The Diversity and Complexity of Parkin Function

Sarah E. Shires, Richard N. Kitsis, Åsa B. Gustafsson

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Parkin is an E3 ubiquitin ligase that mediates mitochondrial autophagy, or mitophagy, in multiple cell types. Although discovered in the context of Parkinson disease, Parkin is also an important regulator of mitophagy in the heart. In addition, while most current work is focused on the role of Parkin in mitophagy, accumulating evidence suggests that Parkin also impacts cellular physiology and function through additional processes. This Viewpoint discusses current controversies on the functional role of Parkin-mediated mitophagy and emerging evidence that Parkin regulates several additional pathways.

Original languageEnglish (US)
Pages (from-to)1234-1236
Number of pages3
JournalCirculation Research
Volume120
Issue number8
DOIs
StatePublished - Apr 14 2017

Keywords

  • autophagy
  • heart
  • mitochondria

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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