Beyond HbA1c and Glucose: the Role of Nontraditional Glycemic Markers in Diabetes Diagnosis, Prognosis, and Management

Christina M. Parrinello, Elizabeth Selvin

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Fasting glucose and hemoglobin A1c (HbA1c) are the standard measures for diagnosis and monitoring of diabetes. There has been recent interest in nontraditional markers of hyperglycemia, including fructosamine, glycated albumin, and 1,5-anhydroglucitol (1,5-AG), as alternatives or adjuncts to standard measures. There is a growing literature linking these nontraditional markers with microvascular and macrovascular complications. Fructosamine and glycated albumin have also been shown to improve identification of persons with diabetes. However, long-term prospective studies with clinical outcomes are lacking. Some modern laboratory assays for fructosamine, glycated albumin, and 1,5-AG have excellent performance. Expanded use of these tests has the potential to improve diabetes care as these measures may overcome limitations of HbA1c in certain patients, complement traditional measures by providing additional information on shorter-term glycemic control, and improve risk stratification for diabetes and its complications. Nonetheless, studies are needed to demonstrate if their routine use will benefit patients and improve outcomes.

Original languageEnglish (US)
JournalCurrent Diabetes Reports
Volume14
Issue number11
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

Fingerprint

Fructosamine
Hemoglobins
Glucose
Diabetes Complications
Hyperglycemia
Fasting
Prospective Studies
glycosylated serum albumin
1,5-anhydroglucitol

Keywords

  • 1,5-Anhydroglucitol
  • Biomarkers
  • Diabetes
  • Fasting glucose
  • Fructosamine
  • Glycated albumin
  • Hemoglobin A1c
  • Hyperglycemia

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Medicine(all)

Cite this

Beyond HbA1c and Glucose : the Role of Nontraditional Glycemic Markers in Diabetes Diagnosis, Prognosis, and Management. / Parrinello, Christina M.; Selvin, Elizabeth.

In: Current Diabetes Reports, Vol. 14, No. 11, 01.11.2014.

Research output: Contribution to journalArticle

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