Beyond frequency: Who is most bothered by vasomotor symptoms?

Rebecca C. Thurston, Joyce T. Bromberger, Hadine Joffe, Nancy E. Avis, Rachel Hess, Carolyn J. Crandall, Yuefang Chang, Robin Green, Karen A. Matthews

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

OBJECTIVE: Most menopausal women report vasomotor symptoms (hot flashes, night sweats). However, not all women with vasomotor symptoms, including frequent symptoms, are bothered by them. The primary aim was to identify correlates of vasomotor symptom bother beyond symptom frequency. DESIGN: The Study of Women's Health Across the Nation participants reporting vasomotor symptoms at annual visit 7 comprised the sample (N = 1,042). Assessments included hot flash and night sweats frequency (number per week) and bother (1, not at all- 4, very much). Negative affect (index of depressive symptoms, anxiety, perceived stress, negative mood), symptom sensitivity, sleep problems, and vasomotor symptom duration (number of years) were examined cross-sectionally in relation to bother in ordinal logistic regression models with symptom frequency and covariates. Hot flashes and night sweats were considered separately. RESULTS: In multivariable models controlling for hot flash frequency, negative affect (odds ratio [OR] = 1.27, 95% CI: 1.08-1.51), symptom sensitivity (OR = 1.18, 95% CI: 1.03-1.37), sleep problems (OR = 1.38, 95% CI: 1.04-1.85), poorer health (OR = 1.24, 95% CI: 1.03-1.48), duration of hot flashes (OR = 1.14, 95% CI: 1.06-1.23), younger age (OR = 0.94, 95% CI: 0.89-0.99), and African American race (vs white, OR = 1.59, 95% CI: 1.12-2.26) were associated with hot flash bother. After controlling for night sweats frequency and covariates, sleep problems (OR = 1.84, 95% CI:1.33-2.55) and night sweats duration (OR = 1.10, 95% CI: 1.02-1.20) were associated with night sweats bother. CONCLUSIONS: Beyond frequency, factors associated with bothersome hot flashes include mood, symptom sensitivity, symptom duration, sleep problems, age, and race. Correlates of bothersome night sweats include sleep problems and symptom duration. In addition to reducing frequency, interventions for vasomotor symptoms might consider addressing modifiable factors related to symptom bother.

Original languageEnglish (US)
Pages (from-to)841-847
Number of pages7
JournalMenopause
Volume15
Issue number5
DOIs
StatePublished - Sep 2008

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Hot Flashes
Sweat
Odds Ratio
Sleep
Logistic Models
Women's Health
African Americans
Anxiety
Depression
Health

Keywords

  • Hot flashes
  • Hot flushes
  • Mood
  • Night sweats
  • Sleep
  • Vasomotor symptoms

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Thurston, R. C., Bromberger, J. T., Joffe, H., Avis, N. E., Hess, R., Crandall, C. J., ... Matthews, K. A. (2008). Beyond frequency: Who is most bothered by vasomotor symptoms? Menopause, 15(5), 841-847. https://doi.org/10.1097/gme.0b013e318168f09b

Beyond frequency : Who is most bothered by vasomotor symptoms? / Thurston, Rebecca C.; Bromberger, Joyce T.; Joffe, Hadine; Avis, Nancy E.; Hess, Rachel; Crandall, Carolyn J.; Chang, Yuefang; Green, Robin; Matthews, Karen A.

In: Menopause, Vol. 15, No. 5, 09.2008, p. 841-847.

Research output: Contribution to journalArticle

Thurston, RC, Bromberger, JT, Joffe, H, Avis, NE, Hess, R, Crandall, CJ, Chang, Y, Green, R & Matthews, KA 2008, 'Beyond frequency: Who is most bothered by vasomotor symptoms?', Menopause, vol. 15, no. 5, pp. 841-847. https://doi.org/10.1097/gme.0b013e318168f09b
Thurston RC, Bromberger JT, Joffe H, Avis NE, Hess R, Crandall CJ et al. Beyond frequency: Who is most bothered by vasomotor symptoms? Menopause. 2008 Sep;15(5):841-847. https://doi.org/10.1097/gme.0b013e318168f09b
Thurston, Rebecca C. ; Bromberger, Joyce T. ; Joffe, Hadine ; Avis, Nancy E. ; Hess, Rachel ; Crandall, Carolyn J. ; Chang, Yuefang ; Green, Robin ; Matthews, Karen A. / Beyond frequency : Who is most bothered by vasomotor symptoms?. In: Menopause. 2008 ; Vol. 15, No. 5. pp. 841-847.
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abstract = "OBJECTIVE: Most menopausal women report vasomotor symptoms (hot flashes, night sweats). However, not all women with vasomotor symptoms, including frequent symptoms, are bothered by them. The primary aim was to identify correlates of vasomotor symptom bother beyond symptom frequency. DESIGN: The Study of Women's Health Across the Nation participants reporting vasomotor symptoms at annual visit 7 comprised the sample (N = 1,042). Assessments included hot flash and night sweats frequency (number per week) and bother (1, not at all- 4, very much). Negative affect (index of depressive symptoms, anxiety, perceived stress, negative mood), symptom sensitivity, sleep problems, and vasomotor symptom duration (number of years) were examined cross-sectionally in relation to bother in ordinal logistic regression models with symptom frequency and covariates. Hot flashes and night sweats were considered separately. RESULTS: In multivariable models controlling for hot flash frequency, negative affect (odds ratio [OR] = 1.27, 95{\%} CI: 1.08-1.51), symptom sensitivity (OR = 1.18, 95{\%} CI: 1.03-1.37), sleep problems (OR = 1.38, 95{\%} CI: 1.04-1.85), poorer health (OR = 1.24, 95{\%} CI: 1.03-1.48), duration of hot flashes (OR = 1.14, 95{\%} CI: 1.06-1.23), younger age (OR = 0.94, 95{\%} CI: 0.89-0.99), and African American race (vs white, OR = 1.59, 95{\%} CI: 1.12-2.26) were associated with hot flash bother. After controlling for night sweats frequency and covariates, sleep problems (OR = 1.84, 95{\%} CI:1.33-2.55) and night sweats duration (OR = 1.10, 95{\%} CI: 1.02-1.20) were associated with night sweats bother. CONCLUSIONS: Beyond frequency, factors associated with bothersome hot flashes include mood, symptom sensitivity, symptom duration, sleep problems, age, and race. Correlates of bothersome night sweats include sleep problems and symptom duration. In addition to reducing frequency, interventions for vasomotor symptoms might consider addressing modifiable factors related to symptom bother.",
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AU - Hess, Rachel

AU - Crandall, Carolyn J.

AU - Chang, Yuefang

AU - Green, Robin

AU - Matthews, Karen A.

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N2 - OBJECTIVE: Most menopausal women report vasomotor symptoms (hot flashes, night sweats). However, not all women with vasomotor symptoms, including frequent symptoms, are bothered by them. The primary aim was to identify correlates of vasomotor symptom bother beyond symptom frequency. DESIGN: The Study of Women's Health Across the Nation participants reporting vasomotor symptoms at annual visit 7 comprised the sample (N = 1,042). Assessments included hot flash and night sweats frequency (number per week) and bother (1, not at all- 4, very much). Negative affect (index of depressive symptoms, anxiety, perceived stress, negative mood), symptom sensitivity, sleep problems, and vasomotor symptom duration (number of years) were examined cross-sectionally in relation to bother in ordinal logistic regression models with symptom frequency and covariates. Hot flashes and night sweats were considered separately. RESULTS: In multivariable models controlling for hot flash frequency, negative affect (odds ratio [OR] = 1.27, 95% CI: 1.08-1.51), symptom sensitivity (OR = 1.18, 95% CI: 1.03-1.37), sleep problems (OR = 1.38, 95% CI: 1.04-1.85), poorer health (OR = 1.24, 95% CI: 1.03-1.48), duration of hot flashes (OR = 1.14, 95% CI: 1.06-1.23), younger age (OR = 0.94, 95% CI: 0.89-0.99), and African American race (vs white, OR = 1.59, 95% CI: 1.12-2.26) were associated with hot flash bother. After controlling for night sweats frequency and covariates, sleep problems (OR = 1.84, 95% CI:1.33-2.55) and night sweats duration (OR = 1.10, 95% CI: 1.02-1.20) were associated with night sweats bother. CONCLUSIONS: Beyond frequency, factors associated with bothersome hot flashes include mood, symptom sensitivity, symptom duration, sleep problems, age, and race. Correlates of bothersome night sweats include sleep problems and symptom duration. In addition to reducing frequency, interventions for vasomotor symptoms might consider addressing modifiable factors related to symptom bother.

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KW - Sleep

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