Beta-lactam combination therapy for the treatment of Staphylococcus aureus and Enterococcus species bacteremia: A summary and appraisal of the evidence

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Staphylococcal bacteremia and enterococcal bacteremia are prevalent in hospitalized or recently instrumented patients, and are associated with significant morbidity and mortality. They are often difficult to treat due to the pathogenicity of the organisms, poor response to antibiotics, and increasing development of multidrug resistance. Therefore, there has been increasing interest in combination therapy for the treatment of these infections. The aim of this review was to summarize and assess the evidence supporting combination beta-lactam therapy for both Staphylococcus aureus and Enterococcus species blood stream infections. Currently, there is promising in vitro data but little clinical evidence supporting combination beta-lactam therapy for this indication. Further clinical investigations are needed to elucidate the potential benefits of beta-lactam combination therapy over monotherapy for Gram-positive bacteremia, although combination therapy may be useful in refractory cases of bacteremia that do not respond to standard antibiotic therapy.

Original languageEnglish (US)
Pages (from-to)7-12
Number of pages6
JournalInternational Journal of Infectious Diseases
Volume63
DOIs
StatePublished - Oct 1 2017

Fingerprint

Enterococcus
beta-Lactams
Bacteremia
Staphylococcus aureus
Therapeutics
Anti-Bacterial Agents
Multiple Drug Resistance
Infection
Virulence
Morbidity
Mortality

Keywords

  • Beta-lactam antibiotic therapy
  • Combination antibiotic therapy
  • Enterococcus species
  • Methicillin-resistant Staphylococcus aureus
  • Staphylococcus aureus
  • Vancomycin-resistant Enterococcus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{bf2b2afc74f647ad99496322dc47ce8a,
title = "Beta-lactam combination therapy for the treatment of Staphylococcus aureus and Enterococcus species bacteremia: A summary and appraisal of the evidence",
abstract = "Staphylococcal bacteremia and enterococcal bacteremia are prevalent in hospitalized or recently instrumented patients, and are associated with significant morbidity and mortality. They are often difficult to treat due to the pathogenicity of the organisms, poor response to antibiotics, and increasing development of multidrug resistance. Therefore, there has been increasing interest in combination therapy for the treatment of these infections. The aim of this review was to summarize and assess the evidence supporting combination beta-lactam therapy for both Staphylococcus aureus and Enterococcus species blood stream infections. Currently, there is promising in vitro data but little clinical evidence supporting combination beta-lactam therapy for this indication. Further clinical investigations are needed to elucidate the potential benefits of beta-lactam combination therapy over monotherapy for Gram-positive bacteremia, although combination therapy may be useful in refractory cases of bacteremia that do not respond to standard antibiotic therapy.",
keywords = "Beta-lactam antibiotic therapy, Combination antibiotic therapy, Enterococcus species, Methicillin-resistant Staphylococcus aureus, Staphylococcus aureus, Vancomycin-resistant Enterococcus",
author = "Bartash, {Rachel M.} and Priya Nori",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.ijid.2017.07.019",
language = "English (US)",
volume = "63",
pages = "7--12",
journal = "International Journal of Infectious Diseases",
issn = "1201-9712",
publisher = "Elsevier",

}

TY - JOUR

T1 - Beta-lactam combination therapy for the treatment of Staphylococcus aureus and Enterococcus species bacteremia

T2 - A summary and appraisal of the evidence

AU - Bartash, Rachel M.

AU - Nori, Priya

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Staphylococcal bacteremia and enterococcal bacteremia are prevalent in hospitalized or recently instrumented patients, and are associated with significant morbidity and mortality. They are often difficult to treat due to the pathogenicity of the organisms, poor response to antibiotics, and increasing development of multidrug resistance. Therefore, there has been increasing interest in combination therapy for the treatment of these infections. The aim of this review was to summarize and assess the evidence supporting combination beta-lactam therapy for both Staphylococcus aureus and Enterococcus species blood stream infections. Currently, there is promising in vitro data but little clinical evidence supporting combination beta-lactam therapy for this indication. Further clinical investigations are needed to elucidate the potential benefits of beta-lactam combination therapy over monotherapy for Gram-positive bacteremia, although combination therapy may be useful in refractory cases of bacteremia that do not respond to standard antibiotic therapy.

AB - Staphylococcal bacteremia and enterococcal bacteremia are prevalent in hospitalized or recently instrumented patients, and are associated with significant morbidity and mortality. They are often difficult to treat due to the pathogenicity of the organisms, poor response to antibiotics, and increasing development of multidrug resistance. Therefore, there has been increasing interest in combination therapy for the treatment of these infections. The aim of this review was to summarize and assess the evidence supporting combination beta-lactam therapy for both Staphylococcus aureus and Enterococcus species blood stream infections. Currently, there is promising in vitro data but little clinical evidence supporting combination beta-lactam therapy for this indication. Further clinical investigations are needed to elucidate the potential benefits of beta-lactam combination therapy over monotherapy for Gram-positive bacteremia, although combination therapy may be useful in refractory cases of bacteremia that do not respond to standard antibiotic therapy.

KW - Beta-lactam antibiotic therapy

KW - Combination antibiotic therapy

KW - Enterococcus species

KW - Methicillin-resistant Staphylococcus aureus

KW - Staphylococcus aureus

KW - Vancomycin-resistant Enterococcus

UR - http://www.scopus.com/inward/record.url?scp=85027692258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027692258&partnerID=8YFLogxK

U2 - 10.1016/j.ijid.2017.07.019

DO - 10.1016/j.ijid.2017.07.019

M3 - Review article

C2 - 28789974

AN - SCOPUS:85027692258

VL - 63

SP - 7

EP - 12

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

ER -