TY - JOUR
T1 - Beta-lactam combination therapy for the treatment of Staphylococcus aureus and Enterococcus species bacteremia
T2 - A summary and appraisal of the evidence
AU - Bartash, Rachel
AU - Nori, Priya
N1 - Publisher Copyright:
© 2017 The Authors
PY - 2017/10
Y1 - 2017/10
N2 - Staphylococcal bacteremia and enterococcal bacteremia are prevalent in hospitalized or recently instrumented patients, and are associated with significant morbidity and mortality. They are often difficult to treat due to the pathogenicity of the organisms, poor response to antibiotics, and increasing development of multidrug resistance. Therefore, there has been increasing interest in combination therapy for the treatment of these infections. The aim of this review was to summarize and assess the evidence supporting combination beta-lactam therapy for both Staphylococcus aureus and Enterococcus species blood stream infections. Currently, there is promising in vitro data but little clinical evidence supporting combination beta-lactam therapy for this indication. Further clinical investigations are needed to elucidate the potential benefits of beta-lactam combination therapy over monotherapy for Gram-positive bacteremia, although combination therapy may be useful in refractory cases of bacteremia that do not respond to standard antibiotic therapy.
AB - Staphylococcal bacteremia and enterococcal bacteremia are prevalent in hospitalized or recently instrumented patients, and are associated with significant morbidity and mortality. They are often difficult to treat due to the pathogenicity of the organisms, poor response to antibiotics, and increasing development of multidrug resistance. Therefore, there has been increasing interest in combination therapy for the treatment of these infections. The aim of this review was to summarize and assess the evidence supporting combination beta-lactam therapy for both Staphylococcus aureus and Enterococcus species blood stream infections. Currently, there is promising in vitro data but little clinical evidence supporting combination beta-lactam therapy for this indication. Further clinical investigations are needed to elucidate the potential benefits of beta-lactam combination therapy over monotherapy for Gram-positive bacteremia, although combination therapy may be useful in refractory cases of bacteremia that do not respond to standard antibiotic therapy.
KW - Beta-lactam antibiotic therapy
KW - Combination antibiotic therapy
KW - Enterococcus species
KW - Methicillin-resistant Staphylococcus aureus
KW - Staphylococcus aureus
KW - Vancomycin-resistant Enterococcus
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U2 - 10.1016/j.ijid.2017.07.019
DO - 10.1016/j.ijid.2017.07.019
M3 - Review article
C2 - 28789974
AN - SCOPUS:85027692258
SN - 1201-9712
VL - 63
SP - 7
EP - 12
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -