Beta-2-microglobulin concentrations in pediatric human immunodeficiency virus infection

Maadhava Ellaurie, Arye Rubinstein

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Serum concentrations of beta-2-microglobulin (B2-M) were correlated with disease outcome in 40 children infected by the human immunodeficiency virus. Serum B2-M serum concentrations below 3.0 mg/100 ml or decreasing concentrations were indicative of a stable disease course but were also noted preterminally in lymphopenic children. Of 20 patients with B2-M concentrations above 3.0 mg/liter, 12 had a progressive disease course and 8 remained stable. In the latter 8 patients the B2-M values decreased with time. Elevated B2-M concentrations were also noted in infants younger than 1 year of age and denoted active human immunodeficiency virus infection. B2-M serum concentrations are a useful prognostic marker in human immunodeficiency virus-infected children.

Original languageEnglish (US)
Pages (from-to)807-809
Number of pages3
JournalPediatric Infectious Disease Journal
Volume9
Issue number11
DOIs
StatePublished - Nov 1990

Keywords

  • Acquired immunodeficiency syndrome
  • Beta-2-microglobulin
  • Early markers
  • Human immunodeficiency virus infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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