Beneficial influence of capsaicin on lipid peroxidation, membrane-bound enzymes and glycoprotein profile during experimental lung carcinogenesis

P. Anandakumar, S. Jagan, S. Kamaraj, G. Ramakrishnan, A. A. Titto, T. Devaki

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

This study was designed to examine the impact of a principal component of hot red peppers and chilli peppers, capsaicin, on alterations in lipid peroxidation, membrane-bound enzyme profiles and glycoprotein levels during benzo(a)pyrene (BP)-induced lung cancer in Swiss albino mice. BP (50 mgkg -1) induced deleterious changes that were that revealed by alterations in lipid peroxidation, membrane-bound enzyme (Na+/K +ATPase, Ca2+ATPase and Mg2+ATPase) activity, levels of total protein and protein-bound carbohydrate components (sialic acid, hexose, hexosamine, hexuronic acid and fucose). Pre-co-treatment with capsaicin (10 mg kg-1) restored the detrimental effects induced by BP, indicating its protective role in BP-induced lung cancer.

Original languageEnglish (US)
Pages (from-to)803-808
Number of pages6
JournalJournal of Pharmacy and Pharmacology
Volume60
Issue number6
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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