Beneficial influence of capsaicin on lipid peroxidation, membrane-bound enzymes and glycoprotein profile during experimental lung carcinogenesis

P. Anandakumar, S. Jagan, S. Kamaraj, G. Ramakrishnan, Titto A. Augustine, T. Devaki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This study was designed to examine the impact of a principal component of hot red peppers and chilli peppers, capsaicin, on alterations in lipid peroxidation, membrane-bound enzyme profiles and glycoprotein levels during benzo(a)pyrene (BP)-induced lung cancer in Swiss albino mice. BP (50 mgkg -1) induced deleterious changes that were that revealed by alterations in lipid peroxidation, membrane-bound enzyme (Na+/K +ATPase, Ca2+ATPase and Mg2+ATPase) activity, levels of total protein and protein-bound carbohydrate components (sialic acid, hexose, hexosamine, hexuronic acid and fucose). Pre-co-treatment with capsaicin (10 mg kg-1) restored the detrimental effects induced by BP, indicating its protective role in BP-induced lung cancer.

Original languageEnglish (US)
Pages (from-to)803-808
Number of pages6
JournalJournal of Pharmacy and Pharmacology
Volume60
Issue number6
DOIs
StatePublished - Jun 2008
Externally publishedYes

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Capsicum
Capsaicin
Membrane Glycoproteins
Lipid Peroxidation
Carcinogenesis
Lung
Lung Neoplasms
Hexuronic Acids
Enzymes
Hexosamines
Ca(2+) Mg(2+)-ATPase
Hexoses
Fucose
Membranes
Calcium-Transporting ATPases
Benzo(a)pyrene
N-Acetylneuraminic Acid
Glycoproteins
Proteins
Carbohydrates

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Beneficial influence of capsaicin on lipid peroxidation, membrane-bound enzymes and glycoprotein profile during experimental lung carcinogenesis. / Anandakumar, P.; Jagan, S.; Kamaraj, S.; Ramakrishnan, G.; Augustine, Titto A.; Devaki, T.

In: Journal of Pharmacy and Pharmacology, Vol. 60, No. 6, 06.2008, p. 803-808.

Research output: Contribution to journalArticle

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