Behavioral interventions as a treatment for epilepsy

Sheryl R. Haut, Richard B. Lipton, Susannah Cornes, Alok K. Dwivedi, Rachel Wasson, Sian Cotton, Jeffrey R. Strawn, Michael Privitera

Research output: Contribution to journalArticle

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Abstract

Objective To evaluate the effect of a stress-reduction intervention in participants with medication-resistant epilepsy. Methods Adults with medication-resistant focal epilepsy (n = 66) were recruited from 3 centers and randomized to 1 of 2 interventions: (1) progressive muscle relaxation (PMR) with diaphragmatic breathing, or (2) control focused-Attention activity with extremity movements. Following an 8-week baseline period, participants began 12 weeks of double-blind treatment. Daily self-reported mood and stress ratings plus seizure counts were completed by participants using an electronic diary, and no medication adjustments were permitted. The primary outcome was percent reduction in seizure frequency per 28 days comparing baseline and treatment; secondary outcomes included stress reduction and stress-seizure interaction. Results In the 66 participants in the intention-To-Treat analysis, seizure frequency was reduced from baseline in both treatment groups (PMR: 29%, p < 0.05; focused attention: 25%, p < 0.05). PMR and focused attention did not differ in seizure reduction (p = 0.38), although PMR was associated with stress reduction relative to focused attention (p < 0.05). Daily stress was not a predictor of seizures. Conclusions Both PMR and the focused-Attention groups showed reduced seizure frequency compared to baseline in participants with medication-resistant focal seizures, although the 2 treatments did not differ. PMR was more effective than focused attention in reducing self-reported stress. ClinicalTrials.gov identifier NCT01444183.

Original languageEnglish (US)
Pages (from-to)e963-e970
JournalNeurology
Volume90
Issue number11
DOIs
StatePublished - Mar 13 2018

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Autogenic Training
Epilepsy
Seizures
Therapeutics
Social Adjustment
Intention to Treat Analysis
Partial Epilepsy
Respiration
Extremities

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Haut, S. R., Lipton, R. B., Cornes, S., Dwivedi, A. K., Wasson, R., Cotton, S., ... Privitera, M. (2018). Behavioral interventions as a treatment for epilepsy. Neurology, 90(11), e963-e970. https://doi.org/10.1212/WNL.0000000000005109

Behavioral interventions as a treatment for epilepsy. / Haut, Sheryl R.; Lipton, Richard B.; Cornes, Susannah; Dwivedi, Alok K.; Wasson, Rachel; Cotton, Sian; Strawn, Jeffrey R.; Privitera, Michael.

In: Neurology, Vol. 90, No. 11, 13.03.2018, p. e963-e970.

Research output: Contribution to journalArticle

Haut, SR, Lipton, RB, Cornes, S, Dwivedi, AK, Wasson, R, Cotton, S, Strawn, JR & Privitera, M 2018, 'Behavioral interventions as a treatment for epilepsy', Neurology, vol. 90, no. 11, pp. e963-e970. https://doi.org/10.1212/WNL.0000000000005109
Haut SR, Lipton RB, Cornes S, Dwivedi AK, Wasson R, Cotton S et al. Behavioral interventions as a treatment for epilepsy. Neurology. 2018 Mar 13;90(11):e963-e970. https://doi.org/10.1212/WNL.0000000000005109
Haut, Sheryl R. ; Lipton, Richard B. ; Cornes, Susannah ; Dwivedi, Alok K. ; Wasson, Rachel ; Cotton, Sian ; Strawn, Jeffrey R. ; Privitera, Michael. / Behavioral interventions as a treatment for epilepsy. In: Neurology. 2018 ; Vol. 90, No. 11. pp. e963-e970.
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