Behavioral effects of developmental methylmercury drinking water exposure in rodents

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Early methylmercury (MeHg) exposure can have long-lasting consequences likely arising from impaired developmental processes, the outcome of which has been exposed in several longitudinal studies of affected populations. Given the large number of newborns at an increased risk of learning disabilities associated with in utero MeHg exposure, it is important to study neurobehavioral alterations using ecologically valid and physiologically relevant models. This review highlights the benefits of using the MeHg drinking water exposure paradigm and outlines behavioral outcomes arising from this procedure in rodents. Combination treatments that exacerbate or ameliorate MeHg-induced effects, and possible molecular mechanisms underlying behavioral impairment are also discussed.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalJournal of Trace Elements in Medicine and Biology
Volume28
Issue number2
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Behavior
  • Developmental neurotoxicity
  • Learning
  • Mercury
  • Rodents

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Molecular Medicine

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