Abstract
Early methylmercury (MeHg) exposure can have long-lasting consequences likely arising from impaired developmental processes, the outcome of which has been exposed in several longitudinal studies of affected populations. Given the large number of newborns at an increased risk of learning disabilities associated with in utero MeHg exposure, it is important to study neurobehavioral alterations using ecologically valid and physiologically relevant models. This review highlights the benefits of using the MeHg drinking water exposure paradigm and outlines behavioral outcomes arising from this procedure in rodents. Combination treatments that exacerbate or ameliorate MeHg-induced effects, and possible molecular mechanisms underlying behavioral impairment are also discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 117-124 |
| Number of pages | 8 |
| Journal | Journal of Trace Elements in Medicine and Biology |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2014 |
| Externally published | Yes |
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Keywords
- Behavior
- Developmental neurotoxicity
- Learning
- Mercury
- Rodents
ASJC Scopus subject areas
- Biochemistry
- Inorganic Chemistry
- Molecular Medicine
Cite this
Behavioral effects of developmental methylmercury drinking water exposure in rodents. / Bisen-Hersh, Emily B.; Farina, Marcelo; Barbosa, Fernando; Rocha, Joao B.T.; Aschner, Michael.
In: Journal of Trace Elements in Medicine and Biology, Vol. 28, No. 2, 2014, p. 117-124.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Behavioral effects of developmental methylmercury drinking water exposure in rodents
AU - Bisen-Hersh, Emily B.
AU - Farina, Marcelo
AU - Barbosa, Fernando
AU - Rocha, Joao B.T.
AU - Aschner, Michael
PY - 2014
Y1 - 2014
N2 - Early methylmercury (MeHg) exposure can have long-lasting consequences likely arising from impaired developmental processes, the outcome of which has been exposed in several longitudinal studies of affected populations. Given the large number of newborns at an increased risk of learning disabilities associated with in utero MeHg exposure, it is important to study neurobehavioral alterations using ecologically valid and physiologically relevant models. This review highlights the benefits of using the MeHg drinking water exposure paradigm and outlines behavioral outcomes arising from this procedure in rodents. Combination treatments that exacerbate or ameliorate MeHg-induced effects, and possible molecular mechanisms underlying behavioral impairment are also discussed.
AB - Early methylmercury (MeHg) exposure can have long-lasting consequences likely arising from impaired developmental processes, the outcome of which has been exposed in several longitudinal studies of affected populations. Given the large number of newborns at an increased risk of learning disabilities associated with in utero MeHg exposure, it is important to study neurobehavioral alterations using ecologically valid and physiologically relevant models. This review highlights the benefits of using the MeHg drinking water exposure paradigm and outlines behavioral outcomes arising from this procedure in rodents. Combination treatments that exacerbate or ameliorate MeHg-induced effects, and possible molecular mechanisms underlying behavioral impairment are also discussed.
KW - Behavior
KW - Developmental neurotoxicity
KW - Learning
KW - Mercury
KW - Rodents
UR - http://www.scopus.com/inward/record.url?scp=84898029376&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898029376&partnerID=8YFLogxK
U2 - 10.1016/j.jtemb.2013.09.008
DO - 10.1016/j.jtemb.2013.09.008
M3 - Review article
C2 - 24210169
AN - SCOPUS:84898029376
VL - 28
SP - 117
EP - 124
JO - Journal of Trace Elements in Medicine and Biology
JF - Journal of Trace Elements in Medicine and Biology
SN - 0946-672X
IS - 2
ER -