Behavioral effects of developmental methylmercury drinking water exposure in rodents

Emily B. Bisen-Hersh; Marcelo Farina; Fernando Barbosa; Joao B.T. Rocha; Michael Aschner

doi:10.1016/j.jtemb.2013.09.008

Behavioral effects of developmental methylmercury drinking water exposure in rodents

Emily B. Bisen-Hersh, Marcelo Farina, Fernando Barbosa, Joao B.T. Rocha, Michael Aschner

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Early methylmercury (MeHg) exposure can have long-lasting consequences likely arising from impaired developmental processes, the outcome of which has been exposed in several longitudinal studies of affected populations. Given the large number of newborns at an increased risk of learning disabilities associated with in utero MeHg exposure, it is important to study neurobehavioral alterations using ecologically valid and physiologically relevant models. This review highlights the benefits of using the MeHg drinking water exposure paradigm and outlines behavioral outcomes arising from this procedure in rodents. Combination treatments that exacerbate or ameliorate MeHg-induced effects, and possible molecular mechanisms underlying behavioral impairment are also discussed.

Original language	English (US)
Pages (from-to)	117-124
Number of pages	8
Journal	Journal of Trace Elements in Medicine and Biology
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.jtemb.2013.09.008
State	Published - 2014

Keywords

Behavior
Developmental neurotoxicity
Learning
Mercury
Rodents

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Inorganic Chemistry

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abstract = "Early methylmercury (MeHg) exposure can have long-lasting consequences likely arising from impaired developmental processes, the outcome of which has been exposed in several longitudinal studies of affected populations. Given the large number of newborns at an increased risk of learning disabilities associated with in utero MeHg exposure, it is important to study neurobehavioral alterations using ecologically valid and physiologically relevant models. This review highlights the benefits of using the MeHg drinking water exposure paradigm and outlines behavioral outcomes arising from this procedure in rodents. Combination treatments that exacerbate or ameliorate MeHg-induced effects, and possible molecular mechanisms underlying behavioral impairment are also discussed.",

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