Behavioral effects of developmental methylmercury drinking water exposure in rodents

Emily B. Bisen-Hersh, Marcelo Farina, Fernando Barbosa, Joao B.T. Rocha, Michael Aschner

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Early methylmercury (MeHg) exposure can have long-lasting consequences likely arising from impaired developmental processes, the outcome of which has been exposed in several longitudinal studies of affected populations. Given the large number of newborns at an increased risk of learning disabilities associated with in utero MeHg exposure, it is important to study neurobehavioral alterations using ecologically valid and physiologically relevant models. This review highlights the benefits of using the MeHg drinking water exposure paradigm and outlines behavioral outcomes arising from this procedure in rodents. Combination treatments that exacerbate or ameliorate MeHg-induced effects, and possible molecular mechanisms underlying behavioral impairment are also discussed.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalJournal of Trace Elements in Medicine and Biology
Volume28
Issue number2
DOIs
StatePublished - 2014
Externally publishedYes

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Learning Disorders
Drinking Water
Longitudinal Studies
Rodentia
Population

Keywords

  • Behavior
  • Developmental neurotoxicity
  • Learning
  • Mercury
  • Rodents

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Molecular Medicine

Cite this

Behavioral effects of developmental methylmercury drinking water exposure in rodents. / Bisen-Hersh, Emily B.; Farina, Marcelo; Barbosa, Fernando; Rocha, Joao B.T.; Aschner, Michael.

In: Journal of Trace Elements in Medicine and Biology, Vol. 28, No. 2, 2014, p. 117-124.

Research output: Contribution to journalReview article

Bisen-Hersh, Emily B. ; Farina, Marcelo ; Barbosa, Fernando ; Rocha, Joao B.T. ; Aschner, Michael. / Behavioral effects of developmental methylmercury drinking water exposure in rodents. In: Journal of Trace Elements in Medicine and Biology. 2014 ; Vol. 28, No. 2. pp. 117-124.
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