Abstract
Early methylmercury (MeHg) exposure can have long-lasting consequences likely arising from impaired developmental processes, the outcome of which has been exposed in several longitudinal studies of affected populations. Given the large number of newborns at an increased risk of learning disabilities associated with in utero MeHg exposure, it is important to study neurobehavioral alterations using ecologically valid and physiologically relevant models. This review highlights the benefits of using the MeHg drinking water exposure paradigm and outlines behavioral outcomes arising from this procedure in rodents. Combination treatments that exacerbate or ameliorate MeHg-induced effects, and possible molecular mechanisms underlying behavioral impairment are also discussed.
Original language | English (US) |
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Pages (from-to) | 117-124 |
Number of pages | 8 |
Journal | Journal of Trace Elements in Medicine and Biology |
Volume | 28 |
Issue number | 2 |
DOIs | |
State | Published - 2014 |
Externally published | Yes |
Keywords
- Behavior
- Developmental neurotoxicity
- Learning
- Mercury
- Rodents
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Inorganic Chemistry