BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing

Liang Cao, Liang Zhang, Siyun Chen, Ziqiang Yuan, Shaokun Liu, Xiaotao Shen, Xin Zheng, Xufeng Qi, Kenneth K H Lee, John Yeuk Hon Chan, Dongqing Cai

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

This study indicates that brain-derived neurotrophic factor (BDNF) can promote young cardiac microvascular endothelial cells (CMECs) to migrate via the activation of the BDNF-TrkB-FL-PI3K/Akt pathway, which may benefit angiogenesis after myocardial infarction (MI). However, the ageing of CMECs led to changes in the expression of receptor Trk isoforms in that among the three isoforms (TrkB-FL, TrkB-T1 and TrkB-T2), only one of its truncated isoforms, TrkB-T1, continued to be expressed, which leads to the dysfunction of its ligand, a decrease in the migration of CMECs and increased injury in ageing hearts. This shift in receptor isoforms in aged CMECs, together with changes in the ageing microenvironment, might predispose ageing hearts to decreased angiogenic potential and increased cardiac pathology.

Original languageEnglish (US)
Pages (from-to)3105-3115
Number of pages11
JournalJournal of Cellular and Molecular Medicine
Volume16
Issue number12
DOIs
StatePublished - Dec 2012

Fingerprint

Brain-Derived Neurotrophic Factor
Protein Isoforms
Endothelial Cells
Phosphatidylinositol 3-Kinases
Myocardial Infarction
Pathology
Ligands
Wounds and Injuries

Keywords

  • Ageing
  • BDNF
  • Cardiac microvascular endothelial cells
  • Migration
  • TrkB

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

Cite this

BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing. / Cao, Liang; Zhang, Liang; Chen, Siyun; Yuan, Ziqiang; Liu, Shaokun; Shen, Xiaotao; Zheng, Xin; Qi, Xufeng; Lee, Kenneth K H; Chan, John Yeuk Hon; Cai, Dongqing.

In: Journal of Cellular and Molecular Medicine, Vol. 16, No. 12, 12.2012, p. 3105-3115.

Research output: Contribution to journalArticle

Cao, L, Zhang, L, Chen, S, Yuan, Z, Liu, S, Shen, X, Zheng, X, Qi, X, Lee, KKH, Chan, JYH & Cai, D 2012, 'BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing', Journal of Cellular and Molecular Medicine, vol. 16, no. 12, pp. 3105-3115. https://doi.org/10.1111/j.1582-4934.2012.01621.x
Cao, Liang ; Zhang, Liang ; Chen, Siyun ; Yuan, Ziqiang ; Liu, Shaokun ; Shen, Xiaotao ; Zheng, Xin ; Qi, Xufeng ; Lee, Kenneth K H ; Chan, John Yeuk Hon ; Cai, Dongqing. / BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing. In: Journal of Cellular and Molecular Medicine. 2012 ; Vol. 16, No. 12. pp. 3105-3115.
@article{1d2b53e9fa414cae88cc05e49bf06399,
title = "BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing",
abstract = "This study indicates that brain-derived neurotrophic factor (BDNF) can promote young cardiac microvascular endothelial cells (CMECs) to migrate via the activation of the BDNF-TrkB-FL-PI3K/Akt pathway, which may benefit angiogenesis after myocardial infarction (MI). However, the ageing of CMECs led to changes in the expression of receptor Trk isoforms in that among the three isoforms (TrkB-FL, TrkB-T1 and TrkB-T2), only one of its truncated isoforms, TrkB-T1, continued to be expressed, which leads to the dysfunction of its ligand, a decrease in the migration of CMECs and increased injury in ageing hearts. This shift in receptor isoforms in aged CMECs, together with changes in the ageing microenvironment, might predispose ageing hearts to decreased angiogenic potential and increased cardiac pathology.",
keywords = "Ageing, BDNF, Cardiac microvascular endothelial cells, Migration, TrkB",
author = "Liang Cao and Liang Zhang and Siyun Chen and Ziqiang Yuan and Shaokun Liu and Xiaotao Shen and Xin Zheng and Xufeng Qi and Lee, {Kenneth K H} and Chan, {John Yeuk Hon} and Dongqing Cai",
year = "2012",
month = "12",
doi = "10.1111/j.1582-4934.2012.01621.x",
language = "English (US)",
volume = "16",
pages = "3105--3115",
journal = "Journal of Cellular and Molecular Medicine",
issn = "1582-1838",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing

AU - Cao, Liang

AU - Zhang, Liang

AU - Chen, Siyun

AU - Yuan, Ziqiang

AU - Liu, Shaokun

AU - Shen, Xiaotao

AU - Zheng, Xin

AU - Qi, Xufeng

AU - Lee, Kenneth K H

AU - Chan, John Yeuk Hon

AU - Cai, Dongqing

PY - 2012/12

Y1 - 2012/12

N2 - This study indicates that brain-derived neurotrophic factor (BDNF) can promote young cardiac microvascular endothelial cells (CMECs) to migrate via the activation of the BDNF-TrkB-FL-PI3K/Akt pathway, which may benefit angiogenesis after myocardial infarction (MI). However, the ageing of CMECs led to changes in the expression of receptor Trk isoforms in that among the three isoforms (TrkB-FL, TrkB-T1 and TrkB-T2), only one of its truncated isoforms, TrkB-T1, continued to be expressed, which leads to the dysfunction of its ligand, a decrease in the migration of CMECs and increased injury in ageing hearts. This shift in receptor isoforms in aged CMECs, together with changes in the ageing microenvironment, might predispose ageing hearts to decreased angiogenic potential and increased cardiac pathology.

AB - This study indicates that brain-derived neurotrophic factor (BDNF) can promote young cardiac microvascular endothelial cells (CMECs) to migrate via the activation of the BDNF-TrkB-FL-PI3K/Akt pathway, which may benefit angiogenesis after myocardial infarction (MI). However, the ageing of CMECs led to changes in the expression of receptor Trk isoforms in that among the three isoforms (TrkB-FL, TrkB-T1 and TrkB-T2), only one of its truncated isoforms, TrkB-T1, continued to be expressed, which leads to the dysfunction of its ligand, a decrease in the migration of CMECs and increased injury in ageing hearts. This shift in receptor isoforms in aged CMECs, together with changes in the ageing microenvironment, might predispose ageing hearts to decreased angiogenic potential and increased cardiac pathology.

KW - Ageing

KW - BDNF

KW - Cardiac microvascular endothelial cells

KW - Migration

KW - TrkB

UR - http://www.scopus.com/inward/record.url?scp=84871044464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871044464&partnerID=8YFLogxK

U2 - 10.1111/j.1582-4934.2012.01621.x

DO - 10.1111/j.1582-4934.2012.01621.x

M3 - Article

VL - 16

SP - 3105

EP - 3115

JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

SN - 1582-1838

IS - 12

ER -