BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing

Liang Cao; Liang Zhang; Siyun Chen; Ziqiang Yuan; Shaokun Liu; Xiaotao Shen; Xin Zheng; Xufeng Qi; Kenneth K.H. Lee; John Yeuk Hon Chan; Dongqing Cai

doi:10.1111/j.1582-4934.2012.01621.x

BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing

Liang Cao, Liang Zhang, Siyun Chen, Ziqiang Yuan, Shaokun Liu, Xiaotao Shen, Xin Zheng, Xufeng Qi, Kenneth K.H. Lee, John Yeuk Hon Chan, Dongqing Cai

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35 Scopus citations

Abstract

This study indicates that brain-derived neurotrophic factor (BDNF) can promote young cardiac microvascular endothelial cells (CMECs) to migrate via the activation of the BDNF-TrkB-FL-PI3K/Akt pathway, which may benefit angiogenesis after myocardial infarction (MI). However, the ageing of CMECs led to changes in the expression of receptor Trk isoforms in that among the three isoforms (TrkB-FL, TrkB-T1 and TrkB-T2), only one of its truncated isoforms, TrkB-T1, continued to be expressed, which leads to the dysfunction of its ligand, a decrease in the migration of CMECs and increased injury in ageing hearts. This shift in receptor isoforms in aged CMECs, together with changes in the ageing microenvironment, might predispose ageing hearts to decreased angiogenic potential and increased cardiac pathology.

Original language	English (US)
Pages (from-to)	3105-3115
Number of pages	11
Journal	Journal of Cellular and Molecular Medicine
Volume	16
Issue number	12
DOIs	https://doi.org/10.1111/j.1582-4934.2012.01621.x
State	Published - Dec 2012

Keywords

Ageing
BDNF
Cardiac microvascular endothelial cells
Migration
TrkB

ASJC Scopus subject areas

Molecular Medicine
Cell Biology

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10.1111/j.1582-4934.2012.01621.x

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title = "BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing",

abstract = "This study indicates that brain-derived neurotrophic factor (BDNF) can promote young cardiac microvascular endothelial cells (CMECs) to migrate via the activation of the BDNF-TrkB-FL-PI3K/Akt pathway, which may benefit angiogenesis after myocardial infarction (MI). However, the ageing of CMECs led to changes in the expression of receptor Trk isoforms in that among the three isoforms (TrkB-FL, TrkB-T1 and TrkB-T2), only one of its truncated isoforms, TrkB-T1, continued to be expressed, which leads to the dysfunction of its ligand, a decrease in the migration of CMECs and increased injury in ageing hearts. This shift in receptor isoforms in aged CMECs, together with changes in the ageing microenvironment, might predispose ageing hearts to decreased angiogenic potential and increased cardiac pathology.",

keywords = "Ageing, BDNF, Cardiac microvascular endothelial cells, Migration, TrkB",

author = "Liang Cao and Liang Zhang and Siyun Chen and Ziqiang Yuan and Shaokun Liu and Xiaotao Shen and Xin Zheng and Xufeng Qi and Lee, {Kenneth K.H.} and Chan, {John Yeuk Hon} and Dongqing Cai",

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doi = "10.1111/j.1582-4934.2012.01621.x",

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AU - Cao, Liang

AU - Zhang, Liang

AU - Chen, Siyun

AU - Yuan, Ziqiang

AU - Liu, Shaokun

AU - Shen, Xiaotao

AU - Zheng, Xin

AU - Qi, Xufeng

AU - Lee, Kenneth K.H.

AU - Chan, John Yeuk Hon

AU - Cai, Dongqing

PY - 2012/12

Y1 - 2012/12

N2 - This study indicates that brain-derived neurotrophic factor (BDNF) can promote young cardiac microvascular endothelial cells (CMECs) to migrate via the activation of the BDNF-TrkB-FL-PI3K/Akt pathway, which may benefit angiogenesis after myocardial infarction (MI). However, the ageing of CMECs led to changes in the expression of receptor Trk isoforms in that among the three isoforms (TrkB-FL, TrkB-T1 and TrkB-T2), only one of its truncated isoforms, TrkB-T1, continued to be expressed, which leads to the dysfunction of its ligand, a decrease in the migration of CMECs and increased injury in ageing hearts. This shift in receptor isoforms in aged CMECs, together with changes in the ageing microenvironment, might predispose ageing hearts to decreased angiogenic potential and increased cardiac pathology.

AB - This study indicates that brain-derived neurotrophic factor (BDNF) can promote young cardiac microvascular endothelial cells (CMECs) to migrate via the activation of the BDNF-TrkB-FL-PI3K/Akt pathway, which may benefit angiogenesis after myocardial infarction (MI). However, the ageing of CMECs led to changes in the expression of receptor Trk isoforms in that among the three isoforms (TrkB-FL, TrkB-T1 and TrkB-T2), only one of its truncated isoforms, TrkB-T1, continued to be expressed, which leads to the dysfunction of its ligand, a decrease in the migration of CMECs and increased injury in ageing hearts. This shift in receptor isoforms in aged CMECs, together with changes in the ageing microenvironment, might predispose ageing hearts to decreased angiogenic potential and increased cardiac pathology.

KW - Ageing

KW - BDNF

KW - Cardiac microvascular endothelial cells

KW - Migration

KW - TrkB

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BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing

Abstract

Keywords

ASJC Scopus subject areas

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