BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing

Liang Cao, Liang Zhang, Siyun Chen, Ziqiang Yuan, Shaokun Liu, Xiaotao Shen, Xin Zheng, Xufeng Qi, Kenneth K.H. Lee, John Yeuk Hon Chan, Dongqing Cai

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

This study indicates that brain-derived neurotrophic factor (BDNF) can promote young cardiac microvascular endothelial cells (CMECs) to migrate via the activation of the BDNF-TrkB-FL-PI3K/Akt pathway, which may benefit angiogenesis after myocardial infarction (MI). However, the ageing of CMECs led to changes in the expression of receptor Trk isoforms in that among the three isoforms (TrkB-FL, TrkB-T1 and TrkB-T2), only one of its truncated isoforms, TrkB-T1, continued to be expressed, which leads to the dysfunction of its ligand, a decrease in the migration of CMECs and increased injury in ageing hearts. This shift in receptor isoforms in aged CMECs, together with changes in the ageing microenvironment, might predispose ageing hearts to decreased angiogenic potential and increased cardiac pathology.

Original languageEnglish (US)
Pages (from-to)3105-3115
Number of pages11
JournalJournal of Cellular and Molecular Medicine
Volume16
Issue number12
DOIs
StatePublished - Dec 2012

Keywords

  • Ageing
  • BDNF
  • Cardiac microvascular endothelial cells
  • Migration
  • TrkB

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

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  • Cite this

    Cao, L., Zhang, L., Chen, S., Yuan, Z., Liu, S., Shen, X., Zheng, X., Qi, X., Lee, K. K. H., Chan, J. Y. H., & Cai, D. (2012). BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing. Journal of Cellular and Molecular Medicine, 16(12), 3105-3115. https://doi.org/10.1111/j.1582-4934.2012.01621.x