Basophilic inclusions in sporadic juvenile amyotrophic lateral sclerosis: an immunocytochemical and ultrastructural study

S. Matsumoto, H. Kusaka, N. Murakami, Y. Hashizume, H. Okazaki, A. Hirano

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

This report concerns immunocytochemical and ultrastructural studies on the basophilic inclusions in two cases of sporadic juvenile amyotrophic lateral sclerosis (ALS). The inclusion had a globular, irregularshaped, or sometimes fragmented appearance. Ultrastructurally, the inclusions consisted mainly of thick filamentous structures associated with granules. Focal neurofilamentous accumulations were occasionally observed among the granulofilamentous structures. The basophilic inclusions occasionally showed granular reaction product deposits with an antibody to ubiquitin. The inclusions did not react with antibodies to phosphorylated neurofilament and to tau protein.

Original languageEnglish (US)
Pages (from-to)579-583
Number of pages5
JournalActa neuropathologica
Volume83
Issue number6
DOIs
StatePublished - May 1 1992

Keywords

  • Basophilic inclusion
  • Juvenile amvotrophic lateral sclerosis
  • Ubiquitin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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