Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes

D. W. Dickson; S. H. Yen; K. I. Suzuki; P. Davies; J. H. Garcia; A. Hirano

doi:10.1007/BF00688042

Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes

D. W. Dickson, S. H. Yen, K. I. Suzuki, P. Davies, J. H. Garcia, A. Hirano

Pathology

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these conditions the ballooned neurons contain phosphorylated epitopes recognized by monoclonal antibodies to neurofilaments, but not epitopes unique to Alzheimer neurofibrillary tangles and Pick bodies. The morphological features and immunohistochemical properties of ballooned neurons in these disorders bear resemblance to swollen neurons produced by neurotoxins that impair axoplasmic transport of neurofilaments. This finding, by analogy, suggests that impaired axoplasmic transport of neurofilaments may be a common mechanism in various dementing neurodegenerative diseases.

Original language	English (US)
Pages (from-to)	216-223
Number of pages	8
Journal	Acta neuropathologica
Volume	71
Issue number	3-4
DOIs	https://doi.org/10.1007/BF00688042
State	Published - Sep 1986

Keywords

Dementia
Immunohistochemistry
Neurofilament
Phosphorylation

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

Access to Document

10.1007/BF00688042

Cite this

@article{e71e51a443ef48d1a7c2006f55eeac51,

title = "Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes",

abstract = "Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these conditions the ballooned neurons contain phosphorylated epitopes recognized by monoclonal antibodies to neurofilaments, but not epitopes unique to Alzheimer neurofibrillary tangles and Pick bodies. The morphological features and immunohistochemical properties of ballooned neurons in these disorders bear resemblance to swollen neurons produced by neurotoxins that impair axoplasmic transport of neurofilaments. This finding, by analogy, suggests that impaired axoplasmic transport of neurofilaments may be a common mechanism in various dementing neurodegenerative diseases.",

keywords = "Dementia, Immunohistochemistry, Neurofilament, Phosphorylation",

author = "Dickson, {D. W.} and Yen, {S. H.} and Suzuki, {K. I.} and P. Davies and Garcia, {J. H.} and A. Hirano",

year = "1986",

month = sep,

doi = "10.1007/BF00688042",

language = "English (US)",

volume = "71",

pages = "216--223",

journal = "Acta neuropathologica",

issn = "0001-6322",

publisher = "Springer Verlag",

number = "3-4",

}

TY - JOUR

T1 - Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes

AU - Dickson, D. W.

AU - Yen, S. H.

AU - Suzuki, K. I.

AU - Davies, P.

AU - Garcia, J. H.

AU - Hirano, A.

PY - 1986/9

Y1 - 1986/9

N2 - Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these conditions the ballooned neurons contain phosphorylated epitopes recognized by monoclonal antibodies to neurofilaments, but not epitopes unique to Alzheimer neurofibrillary tangles and Pick bodies. The morphological features and immunohistochemical properties of ballooned neurons in these disorders bear resemblance to swollen neurons produced by neurotoxins that impair axoplasmic transport of neurofilaments. This finding, by analogy, suggests that impaired axoplasmic transport of neurofilaments may be a common mechanism in various dementing neurodegenerative diseases.

AB - Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these conditions the ballooned neurons contain phosphorylated epitopes recognized by monoclonal antibodies to neurofilaments, but not epitopes unique to Alzheimer neurofibrillary tangles and Pick bodies. The morphological features and immunohistochemical properties of ballooned neurons in these disorders bear resemblance to swollen neurons produced by neurotoxins that impair axoplasmic transport of neurofilaments. This finding, by analogy, suggests that impaired axoplasmic transport of neurofilaments may be a common mechanism in various dementing neurodegenerative diseases.

KW - Dementia

KW - Immunohistochemistry

KW - Neurofilament

KW - Phosphorylation

UR - http://www.scopus.com/inward/record.url?scp=0022871177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022871177&partnerID=8YFLogxK

U2 - 10.1007/BF00688042

DO - 10.1007/BF00688042

M3 - Article

C2 - 2432750

AN - SCOPUS:0022871177

SN - 0001-6322

VL - 71

SP - 216

EP - 223

JO - Acta neuropathologica

JF - Acta neuropathologica

IS - 3-4

ER -

Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this