Balloon-expandable versus self-expandable valves in transcatheter aortic valve implantation: Complications and outcomes from a large international patient cohort

Astrid C. van Nieuwkerk, Raquel B. Santos, Leire Andraka, Didier Tchetche, Fabio S. de Brito, Marco Barbanti, Ran Kornowski, Azeem Latib, Augusto D’onofrio, Flavio Ribichini, Francisco Ten, Nicolas Dumonteil, Jan Baan, Jan J. Piek, Alexandre Abizaid, Samantha Sartori, Paola D’errigo, Giuseppe Tarantini, Mattia Lunardi, Katia OrvinMatteo Pagnesi, Juan Manuel Nogales-Asensio, Angie Ghattas, George Dangas, Roxana Mehran, Ronak Delewi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Both balloon-expandable (BE) and self-expandable (SE) valves for tran-scatheter aortic valve implantation (TAVI) are broadly used in clinical practice. However, adequately powered randomized controlled trials comparing these two valve designs are lacking. Methods: The CENTER-study included 12,381 patients undergoing transfemoral TAVI. Patients undergoing TAVI with a BE-valve (n = 4096) were compared to patients undergoing TAVI with an SE-valve (n = 4096) after propensity score matching. Clinical outcomes including one-year mortality and stroke rates were assessed. Results: In the matched population of n = 5410 patients, the mean age was 81 ± 3 years, 60% was female, and the STS-PROM predicted 30-day mortality was 6.2% (IQR 4.0–12.4). One-year mortality was not different between patients treated with BE-or SE-valves (BE: 16.4% vs. SE: 17.0%, Relative Risk 1.04, 95%CI 0.02–1.21, p = 0.57). One-year stroke rates were also comparable (BE: 4.9% vs. SE: 5.3%, RR 1.09, 95%CI 0.86–1.37, p = 0.48). Conclusion: This study suggests that one-year mortality and stroke rates were comparable in patients with severe aortic valve stenosis undergoing TAVI with either BE or SE-valves.

Original languageEnglish (US)
Article number4005
JournalJournal of Clinical Medicine
Volume10
Issue number17
DOIs
StatePublished - Sep 2021

Keywords

  • Aortic valve stenosis
  • Balloon-expandable
  • Mortality
  • Self-expandable
  • Stroke
  • Transcatheter aortic valve implantation

ASJC Scopus subject areas

  • Medicine(all)

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