Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The GCN5-related N-acetyltransferases family (GNAT) is an important family of proteins that includes more than 100000 members among eukaryotes and prokaryotes. Acetylation appears as a major regulatory post-translational modification and is as widespread as phosphorylation. N-Acetyltransferases transfer an acetyl group from acetyl-CoA to a large array of substrates, from small molecules such as aminoglycoside antibiotics to macromolecules. Acetylation of proteins can occur at two different positions, either at the amino-terminal end (αN-acetylation) or at the ε-amino group (εN-acetylation) of an internal lysine residue. GNAT members have been classified into different groups on the basis of their substrate specificity, and in spite of a very low primary sequence identity, GNAT proteins display a common and conserved fold. This Current Topic reviews the different classes of bacterial GNAT proteins, their functions, their structural characteristics, and their mechanism of action.

Original languageEnglish (US)
Pages (from-to)989-1002
Number of pages14
JournalBiochemistry
Volume55
Issue number7
DOIs
StatePublished - Mar 1 2016

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Acetyltransferases
Acetylation
Proteins
Acetyl Coenzyme A
Phosphorylation
Aminoglycosides
Substrates
Post Translational Protein Processing
Substrate Specificity
Eukaryota
Macromolecules
Lysine
Anti-Bacterial Agents
Molecules

ASJC Scopus subject areas

  • Biochemistry

Cite this

Bacterial GCN5-Related N-Acetyltransferases : From Resistance to Regulation. / Favrot, Lorenza; Blanchard, John S.; Vergnolle, Olivia M.

In: Biochemistry, Vol. 55, No. 7, 01.03.2016, p. 989-1002.

Research output: Contribution to journalArticle

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