Bacterial Branched-Chain Amino Acid Biosynthesis: Structures, Mechanisms, and Drugability

Tathyana M. Amorim Franco, John S. Blanchard

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

The eight enzymes responsible for the biosynthesis of the three branched-chain amino acids (l-isoleucine, l-leucine, and l-valine) were identified decades ago using classical genetic approaches based on amino acid auxotrophy. This review will highlight the recent progress in the determination of the three-dimensional structures of these enzymes, their chemical mechanisms, and insights into their suitability as targets for the development of antibacterial agents. Given the enormous rise in bacterial drug resistance to every major class of antibacterial compound, there is a clear and present need for the identification of new antibacterial compounds with nonoverlapping targets to currently used antibacterials that target cell wall, protein, mRNA, and DNA synthesis.

Original languageEnglish (US)
Pages (from-to)5849-5865
Number of pages17
JournalBiochemistry
Volume56
Issue number44
DOIs
StatePublished - Nov 7 2017

Fingerprint

Branched Chain Amino Acids
Biosynthesis
Bacterial Drug Resistance
Isoleucine
Valine
Enzymes
Leucine
Cell Wall
Cells
Anti-Bacterial Agents
Amino Acids
Messenger RNA
DNA
Pharmaceutical Preparations
Proteins

ASJC Scopus subject areas

  • Biochemistry

Cite this

Bacterial Branched-Chain Amino Acid Biosynthesis : Structures, Mechanisms, and Drugability. / Amorim Franco, Tathyana M.; Blanchard, John S.

In: Biochemistry, Vol. 56, No. 44, 07.11.2017, p. 5849-5865.

Research output: Contribution to journalReview article

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