Baclofen-induced cough suppression in cervical spinal cord injury cord injury

Peter Vytautas Dicpinigaitis, David R. Grimm, Marvin Lesser

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: To determine the effect of the GABA-agonist baclofen on cough reflex sensitivity in subjects with cervical spinal cord injury (C-SCI). Baclofen has been shown to inhibit the cough reflex in able-bodied volunteers. Design: Prospective, nonrandomized control trial. Setting: Veterans Affairs medical center with large outpatient SCI population. Participants: Twelve adult males (11 outpatients) with C-SCI chronically maintained on oral baclofen for the treatment of muscle spasm. Intervention: Subjects underwent cough challenge testing with inhaled capsaicin. The concentrations (μM) of capsaicin inducing 2 or more (C2) and 5 or more (C5) coughs were determined. Mean values for log C2 and log C5 were compared with a control group of outpatients with C-SCI not receiving baclofen. Results: Subjects treated with baclofen had a significantly higher cough threshold (diminished cough reflex sensitivity) than control subjects. Mean (± standard error of the mean) values for log C2 in study subjects and controls were 1.28 ±. 16 and .65 ± .15, respectively (p = .009). Mean values for log C5 in subjects receiving baclofen and in control subjects were 2.20 ± .22 and 1.43 ± .23, respectively (p = .024). Subjects and controls did not differ in terms of age, spirometric parameters, or duration of injury. Conclusions: The results suggest that chronic therapy with baclofen diminishes cough reflex sensitivity in subjects with C-SCI. The clinical significance of this finding remains to be elucidated. (C) 2000 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation.

Original languageEnglish (US)
Pages (from-to)921-923
Number of pages3
JournalArchives of Physical Medicine and Rehabilitation
Volume81
Issue number7
DOIs
StatePublished - Jul 2000

Fingerprint

Baclofen
Spinal Cord Injuries
Cough
Wounds and Injuries
Reflex
Outpatients
Capsaicin
GABA Agonists
Spasm
Veterans
Cervical Cord
Volunteers
Control Groups
Therapeutics
Population

Keywords

  • Baclofen
  • Capsaicin
  • Cough
  • Rehabilitation
  • Spinal cord injuries
  • Tetraplegia

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Baclofen-induced cough suppression in cervical spinal cord injury cord injury. / Dicpinigaitis, Peter Vytautas; Grimm, David R.; Lesser, Marvin.

In: Archives of Physical Medicine and Rehabilitation, Vol. 81, No. 7, 07.2000, p. 921-923.

Research output: Contribution to journalArticle

@article{99fd1e0aac804fce9f3568f35b70b744,
title = "Baclofen-induced cough suppression in cervical spinal cord injury cord injury",
abstract = "Objective: To determine the effect of the GABA-agonist baclofen on cough reflex sensitivity in subjects with cervical spinal cord injury (C-SCI). Baclofen has been shown to inhibit the cough reflex in able-bodied volunteers. Design: Prospective, nonrandomized control trial. Setting: Veterans Affairs medical center with large outpatient SCI population. Participants: Twelve adult males (11 outpatients) with C-SCI chronically maintained on oral baclofen for the treatment of muscle spasm. Intervention: Subjects underwent cough challenge testing with inhaled capsaicin. The concentrations (μM) of capsaicin inducing 2 or more (C2) and 5 or more (C5) coughs were determined. Mean values for log C2 and log C5 were compared with a control group of outpatients with C-SCI not receiving baclofen. Results: Subjects treated with baclofen had a significantly higher cough threshold (diminished cough reflex sensitivity) than control subjects. Mean (± standard error of the mean) values for log C2 in study subjects and controls were 1.28 ±. 16 and .65 ± .15, respectively (p = .009). Mean values for log C5 in subjects receiving baclofen and in control subjects were 2.20 ± .22 and 1.43 ± .23, respectively (p = .024). Subjects and controls did not differ in terms of age, spirometric parameters, or duration of injury. Conclusions: The results suggest that chronic therapy with baclofen diminishes cough reflex sensitivity in subjects with C-SCI. The clinical significance of this finding remains to be elucidated. (C) 2000 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation.",
keywords = "Baclofen, Capsaicin, Cough, Rehabilitation, Spinal cord injuries, Tetraplegia",
author = "Dicpinigaitis, {Peter Vytautas} and Grimm, {David R.} and Marvin Lesser",
year = "2000",
month = "7",
doi = "10.1053/apmr.2000.5612",
language = "English (US)",
volume = "81",
pages = "921--923",
journal = "Archives of Physical Medicine and Rehabilitation",
issn = "0003-9993",
publisher = "W.B. Saunders Ltd",
number = "7",

}

TY - JOUR

T1 - Baclofen-induced cough suppression in cervical spinal cord injury cord injury

AU - Dicpinigaitis, Peter Vytautas

AU - Grimm, David R.

AU - Lesser, Marvin

PY - 2000/7

Y1 - 2000/7

N2 - Objective: To determine the effect of the GABA-agonist baclofen on cough reflex sensitivity in subjects with cervical spinal cord injury (C-SCI). Baclofen has been shown to inhibit the cough reflex in able-bodied volunteers. Design: Prospective, nonrandomized control trial. Setting: Veterans Affairs medical center with large outpatient SCI population. Participants: Twelve adult males (11 outpatients) with C-SCI chronically maintained on oral baclofen for the treatment of muscle spasm. Intervention: Subjects underwent cough challenge testing with inhaled capsaicin. The concentrations (μM) of capsaicin inducing 2 or more (C2) and 5 or more (C5) coughs were determined. Mean values for log C2 and log C5 were compared with a control group of outpatients with C-SCI not receiving baclofen. Results: Subjects treated with baclofen had a significantly higher cough threshold (diminished cough reflex sensitivity) than control subjects. Mean (± standard error of the mean) values for log C2 in study subjects and controls were 1.28 ±. 16 and .65 ± .15, respectively (p = .009). Mean values for log C5 in subjects receiving baclofen and in control subjects were 2.20 ± .22 and 1.43 ± .23, respectively (p = .024). Subjects and controls did not differ in terms of age, spirometric parameters, or duration of injury. Conclusions: The results suggest that chronic therapy with baclofen diminishes cough reflex sensitivity in subjects with C-SCI. The clinical significance of this finding remains to be elucidated. (C) 2000 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation.

AB - Objective: To determine the effect of the GABA-agonist baclofen on cough reflex sensitivity in subjects with cervical spinal cord injury (C-SCI). Baclofen has been shown to inhibit the cough reflex in able-bodied volunteers. Design: Prospective, nonrandomized control trial. Setting: Veterans Affairs medical center with large outpatient SCI population. Participants: Twelve adult males (11 outpatients) with C-SCI chronically maintained on oral baclofen for the treatment of muscle spasm. Intervention: Subjects underwent cough challenge testing with inhaled capsaicin. The concentrations (μM) of capsaicin inducing 2 or more (C2) and 5 or more (C5) coughs were determined. Mean values for log C2 and log C5 were compared with a control group of outpatients with C-SCI not receiving baclofen. Results: Subjects treated with baclofen had a significantly higher cough threshold (diminished cough reflex sensitivity) than control subjects. Mean (± standard error of the mean) values for log C2 in study subjects and controls were 1.28 ±. 16 and .65 ± .15, respectively (p = .009). Mean values for log C5 in subjects receiving baclofen and in control subjects were 2.20 ± .22 and 1.43 ± .23, respectively (p = .024). Subjects and controls did not differ in terms of age, spirometric parameters, or duration of injury. Conclusions: The results suggest that chronic therapy with baclofen diminishes cough reflex sensitivity in subjects with C-SCI. The clinical significance of this finding remains to be elucidated. (C) 2000 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation.

KW - Baclofen

KW - Capsaicin

KW - Cough

KW - Rehabilitation

KW - Spinal cord injuries

KW - Tetraplegia

UR - http://www.scopus.com/inward/record.url?scp=0034234959&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034234959&partnerID=8YFLogxK

U2 - 10.1053/apmr.2000.5612

DO - 10.1053/apmr.2000.5612

M3 - Article

VL - 81

SP - 921

EP - 923

JO - Archives of Physical Medicine and Rehabilitation

JF - Archives of Physical Medicine and Rehabilitation

SN - 0003-9993

IS - 7

ER -