Baclofen-induced bronchoconstriction

Peter Vytautas Dicpinigaitis, D. M. Nierman, A. Miller

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

OBJECTIVE: To report the occurrence of acute bronchospasm in one asthmatic patient and increased bronchial reactivity in another following the administration of a single dose of oral baclofen. CASE SUMMARY: On two separate occasions, a 46-year-old asymptomatic asthmatic man developed dyspnea and chest tightness one hour after the ingestion of baclofen 40 mg. Pulmonary function studies revealed a significant decrease in airflow relative to baseline. A 33-year-old asymptomatic woman with a history of exercise-induced dyspnea and wheezing displayed bronchial hyperresponsiveness to inhaled methacholine 2 hours after ingesting 40 mg of baclofen. The patient had had a negative methacholine challenge test 72 hours earlier. DISCUSSION: The gamma-aminobutyric acid-agonist baclofen has been shown to reduce airway responsiveness to various bronchoconstricting agents in animal studies. The etiology of this seemingly paradoxical response in two patients is unclear, but may offer insight into the neurally mediated airway constriction that occurs in asthma. CONCLUSIONS: Clinicians should be aware of the possibility of baclofen-induced bronchospasm, especially in asthmatic patients.

Original languageEnglish (US)
Pages (from-to)883-884
Number of pages2
JournalAnnals of Pharmacotherapy
Volume27
Issue number7-8
StatePublished - 1993
Externally publishedYes

Fingerprint

Baclofen
Bronchoconstriction
Bronchial Spasm
Methacholine Chloride
Dyspnea
GABA Agonists
Respiratory Sounds
Constriction
Thorax
Asthma
Eating
Exercise
Lung

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Dicpinigaitis, P. V., Nierman, D. M., & Miller, A. (1993). Baclofen-induced bronchoconstriction. Annals of Pharmacotherapy, 27(7-8), 883-884.

Baclofen-induced bronchoconstriction. / Dicpinigaitis, Peter Vytautas; Nierman, D. M.; Miller, A.

In: Annals of Pharmacotherapy, Vol. 27, No. 7-8, 1993, p. 883-884.

Research output: Contribution to journalArticle

Dicpinigaitis, PV, Nierman, DM & Miller, A 1993, 'Baclofen-induced bronchoconstriction', Annals of Pharmacotherapy, vol. 27, no. 7-8, pp. 883-884.
Dicpinigaitis, Peter Vytautas ; Nierman, D. M. ; Miller, A. / Baclofen-induced bronchoconstriction. In: Annals of Pharmacotherapy. 1993 ; Vol. 27, No. 7-8. pp. 883-884.
@article{b4039ae469214e528c3c18cf2db70f6d,
title = "Baclofen-induced bronchoconstriction",
abstract = "OBJECTIVE: To report the occurrence of acute bronchospasm in one asthmatic patient and increased bronchial reactivity in another following the administration of a single dose of oral baclofen. CASE SUMMARY: On two separate occasions, a 46-year-old asymptomatic asthmatic man developed dyspnea and chest tightness one hour after the ingestion of baclofen 40 mg. Pulmonary function studies revealed a significant decrease in airflow relative to baseline. A 33-year-old asymptomatic woman with a history of exercise-induced dyspnea and wheezing displayed bronchial hyperresponsiveness to inhaled methacholine 2 hours after ingesting 40 mg of baclofen. The patient had had a negative methacholine challenge test 72 hours earlier. DISCUSSION: The gamma-aminobutyric acid-agonist baclofen has been shown to reduce airway responsiveness to various bronchoconstricting agents in animal studies. The etiology of this seemingly paradoxical response in two patients is unclear, but may offer insight into the neurally mediated airway constriction that occurs in asthma. CONCLUSIONS: Clinicians should be aware of the possibility of baclofen-induced bronchospasm, especially in asthmatic patients.",
author = "Dicpinigaitis, {Peter Vytautas} and Nierman, {D. M.} and A. Miller",
year = "1993",
language = "English (US)",
volume = "27",
pages = "883--884",
journal = "Annals of Pharmacotherapy",
issn = "1060-0280",
publisher = "Harvey Whitney Books Company",
number = "7-8",

}

TY - JOUR

T1 - Baclofen-induced bronchoconstriction

AU - Dicpinigaitis, Peter Vytautas

AU - Nierman, D. M.

AU - Miller, A.

PY - 1993

Y1 - 1993

N2 - OBJECTIVE: To report the occurrence of acute bronchospasm in one asthmatic patient and increased bronchial reactivity in another following the administration of a single dose of oral baclofen. CASE SUMMARY: On two separate occasions, a 46-year-old asymptomatic asthmatic man developed dyspnea and chest tightness one hour after the ingestion of baclofen 40 mg. Pulmonary function studies revealed a significant decrease in airflow relative to baseline. A 33-year-old asymptomatic woman with a history of exercise-induced dyspnea and wheezing displayed bronchial hyperresponsiveness to inhaled methacholine 2 hours after ingesting 40 mg of baclofen. The patient had had a negative methacholine challenge test 72 hours earlier. DISCUSSION: The gamma-aminobutyric acid-agonist baclofen has been shown to reduce airway responsiveness to various bronchoconstricting agents in animal studies. The etiology of this seemingly paradoxical response in two patients is unclear, but may offer insight into the neurally mediated airway constriction that occurs in asthma. CONCLUSIONS: Clinicians should be aware of the possibility of baclofen-induced bronchospasm, especially in asthmatic patients.

AB - OBJECTIVE: To report the occurrence of acute bronchospasm in one asthmatic patient and increased bronchial reactivity in another following the administration of a single dose of oral baclofen. CASE SUMMARY: On two separate occasions, a 46-year-old asymptomatic asthmatic man developed dyspnea and chest tightness one hour after the ingestion of baclofen 40 mg. Pulmonary function studies revealed a significant decrease in airflow relative to baseline. A 33-year-old asymptomatic woman with a history of exercise-induced dyspnea and wheezing displayed bronchial hyperresponsiveness to inhaled methacholine 2 hours after ingesting 40 mg of baclofen. The patient had had a negative methacholine challenge test 72 hours earlier. DISCUSSION: The gamma-aminobutyric acid-agonist baclofen has been shown to reduce airway responsiveness to various bronchoconstricting agents in animal studies. The etiology of this seemingly paradoxical response in two patients is unclear, but may offer insight into the neurally mediated airway constriction that occurs in asthma. CONCLUSIONS: Clinicians should be aware of the possibility of baclofen-induced bronchospasm, especially in asthmatic patients.

UR - http://www.scopus.com/inward/record.url?scp=0027244572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027244572&partnerID=8YFLogxK

M3 - Article

VL - 27

SP - 883

EP - 884

JO - Annals of Pharmacotherapy

JF - Annals of Pharmacotherapy

SN - 1060-0280

IS - 7-8

ER -