B7x and myeloid-derived suppressor cells in the tumor microenvironment a tale of two cities

Hyungjun Jeon, Kim C. Ohaegbulam, Yael M. Abadi, Xingxing Zang

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A new study demonstrates the tumorigenic functions of B7x and reveals a link between B7x and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. We propose that the binding of B7x to a hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosuppressive functions, hence promoting tumor growth.

Original languageEnglish (US)
Article numbere24744
JournalOncoImmunology
Volume2
Issue number7
DOIs
StatePublished - Sep 4 2013

Keywords

  • B7x
  • Immunosuppression
  • Myeloid-derived suppressor cells
  • Receptor
  • Tumor microenvironment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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