B7x and myeloid-derived suppressor cells in the tumor microenvironment a tale of two cities

Hyungjun Jeon; Kim C. Ohaegbulam; Yael M. Abadi; Xingxing Zang

doi:10.4161/onci.24744

B7x and myeloid-derived suppressor cells in the tumor microenvironment a tale of two cities

Hyungjun Jeon, Kim C. Ohaegbulam, Yael M. Abadi, Xingxing Zang

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A new study demonstrates the tumorigenic functions of B7x and reveals a link between B7x and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. We propose that the binding of B7x to a hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosuppressive functions, hence promoting tumor growth.

Original language	English (US)
Article number	e24744
Journal	OncoImmunology
Volume	2
Issue number	7
DOIs	https://doi.org/10.4161/onci.24744
State	Published - 2013

Keywords

B7x
Immunosuppression
Myeloid-derived suppressor cells
Receptor
Tumor microenvironment

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.24744

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abstract = "A new study demonstrates the tumorigenic functions of B7x and reveals a link between B7x and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. We propose that the binding of B7x to a hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosuppressive functions, hence promoting tumor growth.",

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PY - 2013

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AB - A new study demonstrates the tumorigenic functions of B7x and reveals a link between B7x and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. We propose that the binding of B7x to a hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosuppressive functions, hence promoting tumor growth.

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KW - Myeloid-derived suppressor cells

KW - Receptor

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B7x and myeloid-derived suppressor cells in the tumor microenvironment a tale of two cities

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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