B7x: A widely expressed B7 family member that inhibits T cell activation

Xingxing Zang, P'Ng Loke, Jayon Kim, Kenneth Murphy, Rebecca Waitz, James P. Allison

Research output: Contribution to journalArticle

264 Citations (Scopus)

Abstract

B7 family proteins provide costimulatory signals that regulate T cel responses. Here we report the third set of B7 family-related T cel inhibitory molecules with the identification of a homolog of the B7 family, B7x. It is expressed in immune cells, nonlymphoid tissues, and some tumor cell lines. B7x inhibits cell-cycle progression, proliferation, and cytokine production of both CD4+ and CD8+ T cells. B7x binds a receptor that is expressed on activated, but not resting T cells that is distinct from known CD28 family members. Its receptor may be a recently identified inhibitory molecule, B and T lymphocyte attenuator. These studies identify a costimulatory pathway that may have a unique function in down-regulation of tissue-specific autoimmunity and antitumor responses.

Original languageEnglish (US)
Pages (from-to)10388-10392
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number18
DOIs
StatePublished - Sep 2 2003
Externally publishedYes

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T-Lymphocytes
Tumor Cell Line
Autoimmunity
Cell Cycle
B-Lymphocytes
Down-Regulation
Cytokines
Proteins

Keywords

  • Autoimmunity
  • Costimulation
  • Tumos

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

B7x : A widely expressed B7 family member that inhibits T cell activation. / Zang, Xingxing; Loke, P'Ng; Kim, Jayon; Murphy, Kenneth; Waitz, Rebecca; Allison, James P.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 18, 02.09.2003, p. 10388-10392.

Research output: Contribution to journalArticle

Zang, Xingxing ; Loke, P'Ng ; Kim, Jayon ; Murphy, Kenneth ; Waitz, Rebecca ; Allison, James P. / B7x : A widely expressed B7 family member that inhibits T cell activation. In: Proceedings of the National Academy of Sciences of the United States of America. 2003 ; Vol. 100, No. 18. pp. 10388-10392.
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