B lymphocytes in cell mediated immunity: I. Requirement of T cells or T cell products for antigen induced B cell activation

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17 Citations (Scopus)

Abstract

Although B lymphocytes can be triggered by B cell mitogens and by certain other molecules to produce lymphokines, they do not produce lymphokines when stimulated with specific soluble protein antigens. The authors investigated whether T cell help would enable B cells to produce lymphokines when activated by antigens. Addition of small numbers of T cells to B cell cultures resulted in significant production of a monocyte chemotactic factor. T cells could be replaced by supernates of antigen stimulated T cells, demonstrating both that the chemotactic factor was B cell derived and that T cell help was mediated by a soluble factor. Although the T cell factor was nonantigen specific, B cell activation required the presence of both antigen and T cell factor. Thus, it appears that although dependent upon T cells, B lymphocytes may play an important role in amplification of cell mediated immune responses.

Original languageEnglish (US)
Pages (from-to)1175-1187
Number of pages13
JournalJournal of Experimental Medicine
Volume144
Issue number5
StatePublished - 1976
Externally publishedYes

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CD80 Antigens
Cellular Immunity
B-Lymphocytes
T-Lymphocytes
Lymphokines
TCF Transcription Factors
Antigens
Chemotactic Factors
Mitogens
Monocytes
Cell Culture Techniques

ASJC Scopus subject areas

  • Immunology

Cite this

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abstract = "Although B lymphocytes can be triggered by B cell mitogens and by certain other molecules to produce lymphokines, they do not produce lymphokines when stimulated with specific soluble protein antigens. The authors investigated whether T cell help would enable B cells to produce lymphokines when activated by antigens. Addition of small numbers of T cells to B cell cultures resulted in significant production of a monocyte chemotactic factor. T cells could be replaced by supernates of antigen stimulated T cells, demonstrating both that the chemotactic factor was B cell derived and that T cell help was mediated by a soluble factor. Although the T cell factor was nonantigen specific, B cell activation required the presence of both antigen and T cell factor. Thus, it appears that although dependent upon T cells, B lymphocytes may play an important role in amplification of cell mediated immune responses.",
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T2 - I. Requirement of T cells or T cell products for antigen induced B cell activation

AU - Wahl, S. M.

AU - Rosenstreich, David L.

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AB - Although B lymphocytes can be triggered by B cell mitogens and by certain other molecules to produce lymphokines, they do not produce lymphokines when stimulated with specific soluble protein antigens. The authors investigated whether T cell help would enable B cells to produce lymphokines when activated by antigens. Addition of small numbers of T cells to B cell cultures resulted in significant production of a monocyte chemotactic factor. T cells could be replaced by supernates of antigen stimulated T cells, demonstrating both that the chemotactic factor was B cell derived and that T cell help was mediated by a soluble factor. Although the T cell factor was nonantigen specific, B cell activation required the presence of both antigen and T cell factor. Thus, it appears that although dependent upon T cells, B lymphocytes may play an important role in amplification of cell mediated immune responses.

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