B cells, BAFF/zTNF4, TACI, and systemic lupus erythematosus

Thomas Dörner, Chaim Putterman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

B cells and B-cell/T-cell collaborations are instrumental in the pathophysiology of systemic lupus erythematosus (SLE). This commentary highlights in particular the newly discovered role of B-cell-activating factor (BAFF; also known as TALL-1, THANK, BlyS, and zTNF4) as a positive regulator of B-cell functions, such as B-cell activation and differentiation. Two members of the tumor necrosis factor(TNF)-receptor superfamily were recently identified as receptors for BAFF on B cells. The interaction between BAFF and its receptors may be important in the pathogenesis of lupus. Advances in our understanding of abnormalities in immune regulation in lupus might provide the opportunity to improve our current therapeutic approaches to this disorder.

Original languageEnglish (US)
Pages (from-to)197-199
Number of pages3
JournalArthritis Research
Volume3
Issue number4
DOIs
StatePublished - 2001

Fingerprint

Systemic Lupus Erythematosus
B-Lymphocytes
B-Cell Activation Factor Receptor
B-Cell Activating Factor
Tumor Necrosis Factor Receptors
Cell Differentiation
T-Lymphocytes
Therapeutics

Keywords

  • BAFF
  • SLE
  • TACI
  • TNF
  • TNF receptor superfamily

ASJC Scopus subject areas

  • Rheumatology

Cite this

B cells, BAFF/zTNF4, TACI, and systemic lupus erythematosus. / Dörner, Thomas; Putterman, Chaim.

In: Arthritis Research, Vol. 3, No. 4, 2001, p. 197-199.

Research output: Contribution to journalArticle

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