TY - JOUR
T1 - B-cell biology
AU - Weinstein, Elena
AU - Peeva, Elena
AU - Putterman, Chaim
AU - Diamond, Betty
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2004/2
Y1 - 2004/2
N2 - B-lymphocyte functions can be divided broadly into antigen presentation and production of antibodies. Defects in either of these functions may lead to immunodeficiency or autoimmunity. For the rheumatologist, it is important to understand B-cell development, maturation, and activation to fully comprehend how alterations in these processes shape the B-cell repertoire and can lead eventually to autoimmunity and organ pathology. The goal of this article is to demonstrate how small changes in the selection of the B-cell repertoire, can, over time, and with the necessary environmental influences, lead to rheumatic disease.
AB - B-lymphocyte functions can be divided broadly into antigen presentation and production of antibodies. Defects in either of these functions may lead to immunodeficiency or autoimmunity. For the rheumatologist, it is important to understand B-cell development, maturation, and activation to fully comprehend how alterations in these processes shape the B-cell repertoire and can lead eventually to autoimmunity and organ pathology. The goal of this article is to demonstrate how small changes in the selection of the B-cell repertoire, can, over time, and with the necessary environmental influences, lead to rheumatic disease.
UR - http://www.scopus.com/inward/record.url?scp=1242272834&partnerID=8YFLogxK
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U2 - 10.1016/S0889-857X(03)00109-1
DO - 10.1016/S0889-857X(03)00109-1
M3 - Review article
C2 - 15061573
AN - SCOPUS:1242272834
SN - 0889-857X
VL - 30
SP - 159
EP - 174
JO - Rheumatic Disease Clinics of North America
JF - Rheumatic Disease Clinics of North America
IS - 1
ER -