TY - JOUR
T1 - Azithromycin modulates murine immune responses to pneumococcal conjugate vaccine and inhibits nasal clearance of bacteria
AU - Fernandez, Aracelis D.
AU - Elmore, Monica K.
AU - Metzger, Dennis W.
N1 - Funding Information:
Received 22 January 2004; accepted 22 May 2004; electronically published 13 October 2004. Presented in part: Infectious Diseases Society of America (IDSA) annual meeting, San Francisco, 25–28 October 2001 (abstract 348); Annual Upstate New York Immunology Conference, Bolton Landing, NY, 4–6 November 2001; Pediatric Academic Societies’ annual meeting, Seattle, 3–6 May 2003 (abstract 66); Annual Upstate New York Immunology Conference, Bolton Landing, NY, 9–11 November 2003. Financial support: National Institutes of Health (grant AI41715). a Present affiliation: Boston University School of Public Health, Boston, Massachusetts. Reprints or correspondence: Dr. Aracelis D. Fernandez, Dept. of Pediatrics, Infectious Diseases Division, Albany Medical College, 47 New Scotland Ave., MC-A-88, Albany, NY 12208 (fernana@mail.amc.edu).
PY - 2004/11/15
Y1 - 2004/11/15
N2 - Macrolide antibiotics, including azithromycin, have been implicated in the modulation of host immune responses, independently of their antimicrobial properties. The present work was designed to study the effect that azithromycin has on protective 'humoral immune responses induced by a 7-valent, polysaccharide, pneumococcal conjugate vaccine (PCV7). By use of a murine vaccination/challenge model, it was found that inoculation with azithromycin led to significantly lower primary antibody responses, decreased recall proliferative responses, and, in nasal cavities, impaired clearance of Streptococcus pneumoniae serotype 14 from the nasal cavities. The results demonstrate that azithromycin can be inhibitory with regard to protective immune responsiveness.
AB - Macrolide antibiotics, including azithromycin, have been implicated in the modulation of host immune responses, independently of their antimicrobial properties. The present work was designed to study the effect that azithromycin has on protective 'humoral immune responses induced by a 7-valent, polysaccharide, pneumococcal conjugate vaccine (PCV7). By use of a murine vaccination/challenge model, it was found that inoculation with azithromycin led to significantly lower primary antibody responses, decreased recall proliferative responses, and, in nasal cavities, impaired clearance of Streptococcus pneumoniae serotype 14 from the nasal cavities. The results demonstrate that azithromycin can be inhibitory with regard to protective immune responsiveness.
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U2 - 10.1086/425038
DO - 10.1086/425038
M3 - Article
C2 - 15499531
AN - SCOPUS:8444242083
SN - 0022-1899
VL - 190
SP - 1762
EP - 1766
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 10
ER -
