Azithromycin modulates murine immune responses to pneumococcal conjugate vaccine and inhibits nasal clearance of bacteria

Aracelis D. Fernandez, Monica K. Elmore, Dennis W. Metzger

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Macrolide antibiotics, including azithromycin, have been implicated in the modulation of host immune responses, independently of their antimicrobial properties. The present work was designed to study the effect that azithromycin has on protective 'humoral immune responses induced by a 7-valent, polysaccharide, pneumococcal conjugate vaccine (PCV7). By use of a murine vaccination/challenge model, it was found that inoculation with azithromycin led to significantly lower primary antibody responses, decreased recall proliferative responses, and, in nasal cavities, impaired clearance of Streptococcus pneumoniae serotype 14 from the nasal cavities. The results demonstrate that azithromycin can be inhibitory with regard to protective immune responsiveness.

Original languageEnglish (US)
Pages (from-to)1762-1766
Number of pages5
JournalJournal of Infectious Diseases
Volume190
Issue number10
DOIs
StatePublished - Nov 15 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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