Azidothymidine(AZT)‐induced siderosis

Simeon Pollack, Janet Weaver

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Azidothymidine(AZT) interferes with heme synthesis. This should upregulate the synthesis of transferrin receptors and increase the amount of iron taken up by the cell. We found a 50% increase in the iron content of liver and a 20% increase in the iron content of macrophages in AZT‐treated mice.

Original languageEnglish (US)
Pages (from-to)230-233
Number of pages4
JournalAmerican Journal of Hematology
Volume43
Issue number3
DOIs
StatePublished - Jul 1993

Keywords

  • AIDS
  • iron
  • liver
  • macrophage

ASJC Scopus subject areas

  • Hematology

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