Azidothymidine (AZT)-induced siderosis

Simeon Pollack, J. Weaver

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Azidothymidine (AZT) interferes with heme synthesis. This should upregulate the synthesis of transferrin receptors and increase the amount of iron taken up by the cell. We found a 50% increase in the iron content of liver and a 20% increase in the iron content of macrophages in AZT-treated mice.

Original languageEnglish (US)
Pages (from-to)230-233
Number of pages4
JournalAmerican Journal of Hematology
Volume43
Issue number3
DOIs
StatePublished - 1993

Fingerprint

Siderosis
Zidovudine
Iron
Transferrin Receptors
Heme
Up-Regulation
Macrophages
Liver

Keywords

  • AIDS
  • iron
  • liver
  • macrophage

ASJC Scopus subject areas

  • Hematology

Cite this

Azidothymidine (AZT)-induced siderosis. / Pollack, Simeon; Weaver, J.

In: American Journal of Hematology, Vol. 43, No. 3, 1993, p. 230-233.

Research output: Contribution to journalArticle

Pollack, Simeon ; Weaver, J. / Azidothymidine (AZT)-induced siderosis. In: American Journal of Hematology. 1993 ; Vol. 43, No. 3. pp. 230-233.
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