Aversive effects of subcutaneously injected vasopressin in the rat

independence of the ascending dorsal noradrenergic bundle

Frederick W K Tam, Christopher Chen, Jonathan E. Alpert, Susan D. Iversen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The unconditioned stimulus properties of subcutaneously administered arginine vasopressin (AVP) were examined using place and taste conditioning paradigms. Evidence for an aversive effect of the peptide was found, in general agreement with a previous report, although a high dose of AVP (10 μg) was required. Also investigated was the possible role of the dorsal noradrenergic bundle (DNAB) in conditioned taste aversion established by AVP. Although the DNAB has been proposed as one of the central pathways through which AVP exerts a facilitatory effect on conditioned behaviour, destruction of this pontine-forebrain projection with 6-hydroxydopamine did not appear to alter the aversiveness of the drug in the present study. These results replicate the finding that AVP can serve as an aversive stimulus but also indicate that the aversive properties of the peptide may prove to be dissociable from its ability to enhance the retention of learned behaviour.

Original languageEnglish (US)
Pages (from-to)133-137
Number of pages5
JournalBrain Research
Volume337
Issue number1
DOIs
StatePublished - Jun 24 1985
Externally publishedYes

Fingerprint

Arginine Vasopressin
Vasopressins
Peptides
Aptitude
Oxidopamine
Prosencephalon
Pharmaceutical Preparations

Keywords

  • arginine vasopressin
  • arousal
  • dorsal noradrenergic bundle
  • memory
  • peptide
  • place conditioning
  • rat
  • taste aversion

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Aversive effects of subcutaneously injected vasopressin in the rat : independence of the ascending dorsal noradrenergic bundle. / Tam, Frederick W K; Chen, Christopher; Alpert, Jonathan E.; Iversen, Susan D.

In: Brain Research, Vol. 337, No. 1, 24.06.1985, p. 133-137.

Research output: Contribution to journalArticle

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