We used quantitative autoradiography to determine the density of thyrotropin-releasing hormone (TRH) receptors in discrete regions of spinal cord from four Patients with amvotrophic lateral sclerosis [ALS]. The density and distribution of [3H]-3-methyl-histidine1-TRH binding to TRH receptors differed from reported values in normal individuals, with fewer TRH receptors in lamina II and lamina IX. The diminished concentration of TRH receptors in lamina IX may reflect the loss of motor neurons in ALS.
ASJC Scopus subject areas
- Clinical Neurology