Autoradiographic localization of thyrotropin-releasing hormone receptors in amyotrophic lateral sclerosis spinal cord

Scott Manaker, Lisa H. Shulman, Andrew Winokur, Thomas C. Rainbow

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We used quantitative autoradiography to determine the density of thyrotropin-releasing hormone (TRH) receptors in discrete regions of spinal cord from four Patients with amvotrophic lateral sclerosis [ALS]. The density and distribution of [3H]-3-methyl-histidine1-TRH binding to TRH receptors differed from reported values in normal individuals, with fewer TRH receptors in lamina II and lamina IX. The diminished concentration of TRH receptors in lamina IX may reflect the loss of motor neurons in ALS.

Original languageEnglish (US)
Pages (from-to)1650-1653
Number of pages4
JournalNeurology
Volume35
Issue number11
Publication statusPublished - Nov 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Neurology

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