Autoradiographic localization of thyrotropin-releasing hormone receptors in amyotrophic lateral sclerosis spinal cord

Scott Manaker, Lisa H. Shulman, Andrew Winokur, Thomas C. Rainbow

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We used quantitative autoradiography to determine the density of thyrotropin-releasing hormone (TRH) receptors in discrete regions of spinal cord from four Patients with amvotrophic lateral sclerosis [ALS]. The density and distribution of [<sup>3</sup>H]-3-methyl-histidine<sup>1</sup>-TRH binding to TRH receptors differed from reported values in normal individuals, with fewer TRH receptors in lamina II and lamina IX. The diminished concentration of TRH receptors in lamina IX may reflect the loss of motor neurons in ALS.

Original languageEnglish (US)
Pages (from-to)1650-1653
Number of pages4
JournalNeurology
Volume35
Issue number11
StatePublished - 1985
Externally publishedYes

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Thyrotropin Releasing Hormone Receptors
Amyotrophic Lateral Sclerosis
Spinal Cord
Motor Neuron Disease
Substantia Gelatinosa
Motor Neurons
Autoradiography
Reference Values
Localization
Hormones
Cord

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Autoradiographic localization of thyrotropin-releasing hormone receptors in amyotrophic lateral sclerosis spinal cord. / Manaker, Scott; Shulman, Lisa H.; Winokur, Andrew; Rainbow, Thomas C.

In: Neurology, Vol. 35, No. 11, 1985, p. 1650-1653.

Research output: Contribution to journalArticle

Manaker, Scott ; Shulman, Lisa H. ; Winokur, Andrew ; Rainbow, Thomas C. / Autoradiographic localization of thyrotropin-releasing hormone receptors in amyotrophic lateral sclerosis spinal cord. In: Neurology. 1985 ; Vol. 35, No. 11. pp. 1650-1653.
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