Autoradiographic and functional development of gastric cholecystokinin receptors in the rat

Gary J. Schwartz, Timothy H. Moran, Paul R. McHugh

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

To determine the functional role for and the pharmacological specificity of developing gastrointestinal CCK receptors, in vitro pyloric contractility and autoradiographic CCK receptor binding were examined in pups aged 1-20 days. CCK contracted the gastroduodenal junction at all ages, while nonsulfated CCK-8 (d-CCK) was less potent. Autoradiographic studies revealed CCK binding localized to the gastroduodenal junction throughout development. MK-329, a specific type A CCK receptor antagonist, completely displaced 125I CCK-8 binding at all ages, while d-CCK displaced binding at ages at which d-CCK elicited gastroduodenal contractility. The results demonstrate a physiological role for and pharmacological specificity of neonatal gastroduodenal CCK receptors.

Original languageEnglish (US)
Pages (from-to)1199-1203
Number of pages5
JournalPeptides
Volume11
Issue number6
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Keywords

  • Autoradiography
  • CCK
  • Gastric emptying
  • Ingestive behavior
  • Neonatal rat
  • Ontogeny
  • Pylorus
  • Receptors

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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