Autophagy regulates lipid metabolism

Rajat Singh, Susmita Kaushik, Yongjun Wang, Youqing Xiang, Inna Novak, Masaaki Komatsu, Keiji Tanaka, Ana Maria Cuervo, Mark J. Czaja

Research output: Contribution to journalArticle

1773 Citations (Scopus)

Abstract

The intracellular storage and utilization of lipids are critical to maintain cellular energy homeostasis. During nutrient deprivation, cellular lipids stored as triglycerides in lipid droplets are hydrolysed into fatty acids for energy. A second cellular response to starvation is the induction of autophagy, which delivers intracellular proteins and organelles sequestered in double-membrane vesicles (autophagosomes) to lysosomes for degradation and use as an energy source. Lipolysis and autophagy share similarities in regulation and function but are not known to be interrelated. Here we show a previously unknown function for autophagy in regulating intracellular lipid stores (macrolipophagy). Lipid droplets and autophagic components associated during nutrient deprivation, and inhibition of autophagy in cultured hepatocytes and mouse liver increased triglyceride storage in lipid droplets. This study identifies a critical function for autophagy in lipid metabolism that could have important implications for human diseases with lipid over-accumulation such as those that comprise the metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)1131-1135
Number of pages5
JournalNature
Volume458
Issue number7242
DOIs
StatePublished - Apr 30 2009

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Autophagy
Lipid Metabolism
Lipids
Triglycerides
Food
Lipolysis
Starvation
Lysosomes
Organelles
Hepatocytes
Homeostasis
Fatty Acids
Membranes
Liver
Lipid Droplets
Proteins

ASJC Scopus subject areas

  • General

Cite this

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., ... Czaja, M. J. (2009). Autophagy regulates lipid metabolism. Nature, 458(7242), 1131-1135. https://doi.org/10.1038/nature07976

Autophagy regulates lipid metabolism. / Singh, Rajat; Kaushik, Susmita; Wang, Yongjun; Xiang, Youqing; Novak, Inna; Komatsu, Masaaki; Tanaka, Keiji; Cuervo, Ana Maria; Czaja, Mark J.

In: Nature, Vol. 458, No. 7242, 30.04.2009, p. 1131-1135.

Research output: Contribution to journalArticle

Singh, R, Kaushik, S, Wang, Y, Xiang, Y, Novak, I, Komatsu, M, Tanaka, K, Cuervo, AM & Czaja, MJ 2009, 'Autophagy regulates lipid metabolism', Nature, vol. 458, no. 7242, pp. 1131-1135. https://doi.org/10.1038/nature07976
Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M et al. Autophagy regulates lipid metabolism. Nature. 2009 Apr 30;458(7242):1131-1135. https://doi.org/10.1038/nature07976
Singh, Rajat ; Kaushik, Susmita ; Wang, Yongjun ; Xiang, Youqing ; Novak, Inna ; Komatsu, Masaaki ; Tanaka, Keiji ; Cuervo, Ana Maria ; Czaja, Mark J. / Autophagy regulates lipid metabolism. In: Nature. 2009 ; Vol. 458, No. 7242. pp. 1131-1135.
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