Autophagy, nutrition and immunology

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Turnover of cellular components in lysosomes or autophagy is an essential mechanism for cellular quality control. Added to this cleaning role, autophagy has recently been shown to participate in the dynamic interaction of cells with the surrounding environment by acting as a point of integration of extracellular cues. In this review, we focus on the relationship between autophagy and two types of environmental factors: nutrients and pathogens. We describe their direct effect on autophagy and discuss how the autophagic reaction to these stimuli allows cells to accommodate the requirements of the cellular response to stress, including those specific to the immune responses.

Original languageEnglish (US)
Pages (from-to)2-13
Number of pages12
JournalMolecular aspects of medicine
Volume33
Issue number1
DOIs
StatePublished - Feb 1 2012

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Keywords

  • Aging
  • Antigen presentation
  • Chaperones
  • Lipids
  • Lysosomes
  • Starvation
  • T-cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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