Autophagy in the cellular energetic balance

Rajat Singh; Ana Maria Cuervo

doi:10.1016/j.cmet.2011.04.004

Autophagy in the cellular energetic balance

Rajat Singh, Ana Maria Cuervo

Research output: Contribution to journal › Review article › peer-review

621 Scopus citations

Abstract

Autophagy mediates the degradation of cellular components in lysosomes, assuring removal of altered or dysfunctional proteins and organelles. Autophagy is not only activated in response to cellular damage; in fact, one of its strongest and better-characterized stimuli is starvation. Activation of autophagy when nutrients are scarce allows cells to reutilize their own constituents for energy. Besides protein breakdown, autophagy also contributes to the mobilization of diverse cellular energy stores. This recently discovered interplay between autophagy and lipid and carbohydrate metabolism reveals the existence of a dynamic feedback between autophagy and cellular energy balance.

Original language	English (US)
Pages (from-to)	495-504
Number of pages	10
Journal	Cell metabolism
Volume	13
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2011.04.004
State	Published - May 4 2011

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2011.04.004

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title = "Autophagy in the cellular energetic balance",

abstract = "Autophagy mediates the degradation of cellular components in lysosomes, assuring removal of altered or dysfunctional proteins and organelles. Autophagy is not only activated in response to cellular damage; in fact, one of its strongest and better-characterized stimuli is starvation. Activation of autophagy when nutrients are scarce allows cells to reutilize their own constituents for energy. Besides protein breakdown, autophagy also contributes to the mobilization of diverse cellular energy stores. This recently discovered interplay between autophagy and lipid and carbohydrate metabolism reveals the existence of a dynamic feedback between autophagy and cellular energy balance.",

author = "Rajat Singh and Cuervo, {Ana Maria}",

note = "Funding Information: We thank Dr. Susmita Kaushik and Ms. Samantha J. Orenstein for critically reading the manuscript. Work in our groups is supported by NIH grants AG021904, AG031782, DK041918, NS038370, a Hirsch/Weill-Caulier Career Scientist Award (A.M.C.), and NIH grant DK087776 (R.S.).",

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AU - Singh, Rajat

AU - Cuervo, Ana Maria

N1 - Funding Information: We thank Dr. Susmita Kaushik and Ms. Samantha J. Orenstein for critically reading the manuscript. Work in our groups is supported by NIH grants AG021904, AG031782, DK041918, NS038370, a Hirsch/Weill-Caulier Career Scientist Award (A.M.C.), and NIH grant DK087776 (R.S.).

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N2 - Autophagy mediates the degradation of cellular components in lysosomes, assuring removal of altered or dysfunctional proteins and organelles. Autophagy is not only activated in response to cellular damage; in fact, one of its strongest and better-characterized stimuli is starvation. Activation of autophagy when nutrients are scarce allows cells to reutilize their own constituents for energy. Besides protein breakdown, autophagy also contributes to the mobilization of diverse cellular energy stores. This recently discovered interplay between autophagy and lipid and carbohydrate metabolism reveals the existence of a dynamic feedback between autophagy and cellular energy balance.

AB - Autophagy mediates the degradation of cellular components in lysosomes, assuring removal of altered or dysfunctional proteins and organelles. Autophagy is not only activated in response to cellular damage; in fact, one of its strongest and better-characterized stimuli is starvation. Activation of autophagy when nutrients are scarce allows cells to reutilize their own constituents for energy. Besides protein breakdown, autophagy also contributes to the mobilization of diverse cellular energy stores. This recently discovered interplay between autophagy and lipid and carbohydrate metabolism reveals the existence of a dynamic feedback between autophagy and cellular energy balance.

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Autophagy in the cellular energetic balance

Abstract

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