Abstract
Dysregulation of autophagy with age has been identified as a central mechanism of aging affecting many cells and tissues. T cells do also show decreased activity with age of different autophagic pathways. Here, we will review the current knowledge of the different functions that autophagy has in the regulation of T cell homeostasis, differentiation and function and explore how the age-associated decreased in autophagy activity may contribute to the altered T cell responses that characterize T cell immunosenescence.
Original language | English (US) |
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Article number | 213 |
Journal | Frontiers in Cell and Developmental Biology |
Volume | 7 |
DOIs | |
State | Published - Oct 2 2019 |
Keywords
- T cell
- aging
- autophagy
- chaperone-mediated autophagy
- immunosenescence
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology