Autophagy in T Cell Function and Aging

Research output: Contribution to journalReview article

Abstract

Dysregulation of autophagy with age has been identified as a central mechanism of aging affecting many cells and tissues. T cells do also show decreased activity with age of different autophagic pathways. Here, we will review the current knowledge of the different functions that autophagy has in the regulation of T cell homeostasis, differentiation and function and explore how the age-associated decreased in autophagy activity may contribute to the altered T cell responses that characterize T cell immunosenescence.

Original languageEnglish (US)
Article number213
JournalFrontiers in Cell and Developmental Biology
Volume7
DOIs
StatePublished - Oct 2 2019

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Cell Aging
Autophagy
T-Lymphocytes
Cell Differentiation
Homeostasis

Keywords

  • aging
  • autophagy
  • chaperone-mediated autophagy
  • immunosenescence
  • T cell

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Autophagy in T Cell Function and Aging. / Macian, Fernando.

In: Frontiers in Cell and Developmental Biology, Vol. 7, 213, 02.10.2019.

Research output: Contribution to journalReview article

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