Autophagy: In sickness and in health

Research output: Contribution to journalReview article

629 Scopus citations

Abstract

The degradation of intracellular components in lysosomes (autophagy) has recaptured the attention of cell biologists in recent years. The main reason for this renewed interest is the dissection of the molecular machinery that participates in this process, because the identification of new intracellular elements involved in autophagy has provided new tools to trace, quantify and manipulate autophagy in a growing number of organisms. As a result, a better understanding of the physiological roles of autophagy, the consequences of its malfunctioning and its participation in different pathological processes has emerged. This article reviews our current knowledge of the role of autophagy in disease and the efforts to reconcile its proposed dual function as both a cell protector and a cell killer.

Original languageEnglish (US)
Pages (from-to)70-77
Number of pages8
JournalTrends in Cell Biology
Volume14
Issue number2
DOIs
StatePublished - Feb 2004

ASJC Scopus subject areas

  • Cell Biology

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