Autophagy in nonalcoholic steatohepatitis

Muhammad Amir, Mark J. Czaja

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Autophagy is a critical pathway for the degradation of intracellular components by lysosomes. Established functions for both macroautophagy and chaperone-mediated autophagy in hepatic lipid metabolism, insulin sensitivity and cellular injury suggest a number of potential mechanistic roles for autophagy in nonalcoholic steatohepatitis (NASH). Decreased autophagic function in particular may promote the initial development of hepatic steatosis and progression of steatosis to liver injury. Additional functions of autophagy in immune responses and carcinogenesis may also contribute to the development of NASH and its complications. The impairment in autophagy that occurs with cellular lipid accumulation, obesity and aging may therefore have an important impact on this disease, and agents to augment hepatic autophagy have therapeutic potential in NASH.

Original languageEnglish (US)
Pages (from-to)159-166
Number of pages8
JournalExpert Review of Gastroenterology and Hepatology
Volume5
Issue number2
DOIs
StatePublished - Apr 2011

Fingerprint

Autophagy
Liver
Critical Pathways
Wounds and Injuries
Fatty Liver
Lysosomes
Non-alcoholic Fatty Liver Disease
Lipid Metabolism
Insulin Resistance
Carcinogenesis
Obesity
Lipids

Keywords

  • chaperone-mediated autophagy
  • insulin sensitivity
  • liver injury
  • macroautophagy
  • nonalcoholic fatty liver disease
  • oxidative stress

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Autophagy in nonalcoholic steatohepatitis. / Amir, Muhammad; Czaja, Mark J.

In: Expert Review of Gastroenterology and Hepatology, Vol. 5, No. 2, 04.2011, p. 159-166.

Research output: Contribution to journalArticle

Amir, Muhammad ; Czaja, Mark J. / Autophagy in nonalcoholic steatohepatitis. In: Expert Review of Gastroenterology and Hepatology. 2011 ; Vol. 5, No. 2. pp. 159-166.
@article{0cf9de8f4e894387bf8b09e89fc14d7e,
title = "Autophagy in nonalcoholic steatohepatitis",
abstract = "Autophagy is a critical pathway for the degradation of intracellular components by lysosomes. Established functions for both macroautophagy and chaperone-mediated autophagy in hepatic lipid metabolism, insulin sensitivity and cellular injury suggest a number of potential mechanistic roles for autophagy in nonalcoholic steatohepatitis (NASH). Decreased autophagic function in particular may promote the initial development of hepatic steatosis and progression of steatosis to liver injury. Additional functions of autophagy in immune responses and carcinogenesis may also contribute to the development of NASH and its complications. The impairment in autophagy that occurs with cellular lipid accumulation, obesity and aging may therefore have an important impact on this disease, and agents to augment hepatic autophagy have therapeutic potential in NASH.",
keywords = "chaperone-mediated autophagy, insulin sensitivity, liver injury, macroautophagy, nonalcoholic fatty liver disease, oxidative stress",
author = "Muhammad Amir and Czaja, {Mark J.}",
year = "2011",
month = "4",
doi = "10.1586/egh.11.4",
language = "English (US)",
volume = "5",
pages = "159--166",
journal = "Expert Review of Gastroenterology and Hepatology",
issn = "1747-4124",
publisher = "Expert Reviews Ltd.",
number = "2",

}

TY - JOUR

T1 - Autophagy in nonalcoholic steatohepatitis

AU - Amir, Muhammad

AU - Czaja, Mark J.

PY - 2011/4

Y1 - 2011/4

N2 - Autophagy is a critical pathway for the degradation of intracellular components by lysosomes. Established functions for both macroautophagy and chaperone-mediated autophagy in hepatic lipid metabolism, insulin sensitivity and cellular injury suggest a number of potential mechanistic roles for autophagy in nonalcoholic steatohepatitis (NASH). Decreased autophagic function in particular may promote the initial development of hepatic steatosis and progression of steatosis to liver injury. Additional functions of autophagy in immune responses and carcinogenesis may also contribute to the development of NASH and its complications. The impairment in autophagy that occurs with cellular lipid accumulation, obesity and aging may therefore have an important impact on this disease, and agents to augment hepatic autophagy have therapeutic potential in NASH.

AB - Autophagy is a critical pathway for the degradation of intracellular components by lysosomes. Established functions for both macroautophagy and chaperone-mediated autophagy in hepatic lipid metabolism, insulin sensitivity and cellular injury suggest a number of potential mechanistic roles for autophagy in nonalcoholic steatohepatitis (NASH). Decreased autophagic function in particular may promote the initial development of hepatic steatosis and progression of steatosis to liver injury. Additional functions of autophagy in immune responses and carcinogenesis may also contribute to the development of NASH and its complications. The impairment in autophagy that occurs with cellular lipid accumulation, obesity and aging may therefore have an important impact on this disease, and agents to augment hepatic autophagy have therapeutic potential in NASH.

KW - chaperone-mediated autophagy

KW - insulin sensitivity

KW - liver injury

KW - macroautophagy

KW - nonalcoholic fatty liver disease

KW - oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=79954475565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954475565&partnerID=8YFLogxK

U2 - 10.1586/egh.11.4

DO - 10.1586/egh.11.4

M3 - Article

VL - 5

SP - 159

EP - 166

JO - Expert Review of Gastroenterology and Hepatology

JF - Expert Review of Gastroenterology and Hepatology

SN - 1747-4124

IS - 2

ER -