Autophagy gone awry in neurodegenerative diseases

Esther Wong, Ana Maria Cuervo

Research output: Contribution to journalArticle

599 Citations (Scopus)

Abstract

Autophagy is essential for neuronal homeostasis, and its dysfunction has been directly linked to a growing number of neurodegenerative disorders. The reasons behind autophagic failure in degenerating neurons can be very diverse because of the different steps required for autophagy and the characterization of the molecular players involved in each of them. Understanding the step(s) affected in the autophagic process in each disorder could explain differences in the course of these pathologies and will be essential to developing targeted therapeutic approaches for each disease based on modulation of autophagy. Here we present examples of different types of autophagic dysfunction described in common neurodegenerative disorders and discuss the prospect of exploring some of the recently identified autophagic variants and the interactions among autophagic and non-autophagic proteolytic systems as possible future therapeutic targets.

Original languageEnglish (US)
Pages (from-to)805-811
Number of pages7
JournalNature Neuroscience
Volume13
Issue number7
DOIs
StatePublished - Jul 2010

Fingerprint

Autophagy
Neurodegenerative Diseases
Homeostasis
Pathology
Neurons
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Autophagy gone awry in neurodegenerative diseases. / Wong, Esther; Cuervo, Ana Maria.

In: Nature Neuroscience, Vol. 13, No. 7, 07.2010, p. 805-811.

Research output: Contribution to journalArticle

Wong, Esther ; Cuervo, Ana Maria. / Autophagy gone awry in neurodegenerative diseases. In: Nature Neuroscience. 2010 ; Vol. 13, No. 7. pp. 805-811.
@article{380e1ce9e2b04b67b128acf4d77c4621,
title = "Autophagy gone awry in neurodegenerative diseases",
abstract = "Autophagy is essential for neuronal homeostasis, and its dysfunction has been directly linked to a growing number of neurodegenerative disorders. The reasons behind autophagic failure in degenerating neurons can be very diverse because of the different steps required for autophagy and the characterization of the molecular players involved in each of them. Understanding the step(s) affected in the autophagic process in each disorder could explain differences in the course of these pathologies and will be essential to developing targeted therapeutic approaches for each disease based on modulation of autophagy. Here we present examples of different types of autophagic dysfunction described in common neurodegenerative disorders and discuss the prospect of exploring some of the recently identified autophagic variants and the interactions among autophagic and non-autophagic proteolytic systems as possible future therapeutic targets.",
author = "Esther Wong and Cuervo, {Ana Maria}",
year = "2010",
month = "7",
doi = "10.1038/nn.2575",
language = "English (US)",
volume = "13",
pages = "805--811",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Autophagy gone awry in neurodegenerative diseases

AU - Wong, Esther

AU - Cuervo, Ana Maria

PY - 2010/7

Y1 - 2010/7

N2 - Autophagy is essential for neuronal homeostasis, and its dysfunction has been directly linked to a growing number of neurodegenerative disorders. The reasons behind autophagic failure in degenerating neurons can be very diverse because of the different steps required for autophagy and the characterization of the molecular players involved in each of them. Understanding the step(s) affected in the autophagic process in each disorder could explain differences in the course of these pathologies and will be essential to developing targeted therapeutic approaches for each disease based on modulation of autophagy. Here we present examples of different types of autophagic dysfunction described in common neurodegenerative disorders and discuss the prospect of exploring some of the recently identified autophagic variants and the interactions among autophagic and non-autophagic proteolytic systems as possible future therapeutic targets.

AB - Autophagy is essential for neuronal homeostasis, and its dysfunction has been directly linked to a growing number of neurodegenerative disorders. The reasons behind autophagic failure in degenerating neurons can be very diverse because of the different steps required for autophagy and the characterization of the molecular players involved in each of them. Understanding the step(s) affected in the autophagic process in each disorder could explain differences in the course of these pathologies and will be essential to developing targeted therapeutic approaches for each disease based on modulation of autophagy. Here we present examples of different types of autophagic dysfunction described in common neurodegenerative disorders and discuss the prospect of exploring some of the recently identified autophagic variants and the interactions among autophagic and non-autophagic proteolytic systems as possible future therapeutic targets.

UR - http://www.scopus.com/inward/record.url?scp=77954116814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954116814&partnerID=8YFLogxK

U2 - 10.1038/nn.2575

DO - 10.1038/nn.2575

M3 - Article

VL - 13

SP - 805

EP - 811

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 7

ER -