Autophagy fights disease through cellular self-digestion

Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J. Klionsky

Research output: Contribution to journalReview article

4138 Scopus citations

Abstract

Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health.

Original languageEnglish (US)
Pages (from-to)1069-1075
Number of pages7
JournalNature
Volume451
Issue number7182
DOIs
StatePublished - Feb 28 2008

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Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008). Autophagy fights disease through cellular self-digestion. Nature, 451(7182), 1069-1075. https://doi.org/10.1038/nature06639