Autophagy and the regulation of the immune response

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Autophagy is a highly conserved mechanism of lysosomal-mediated protein degradation that plays a crucial role in maintaining cellular homeostasis by recycling amino acids, reducing the amount of damaged proteins and regulating protein levels in response to extracellular signals. In the last few years specific functions for different forms of autophagy have been identified in many tissues and organs. In the Immune System, autophagy functions range from the elimination infectious agents and the modulation of the inflammatory response, to the selection of antigens for presentation and the regulation of T cell homeostasis and activation. Here, we review the recent advances that have allowed us to better understand why autophagy is a crucial process in the regulation of the innate and adaptive immune responses.

Original languageEnglish (US)
Pages (from-to)475-483
Number of pages9
JournalPharmacological Research
Volume66
Issue number6
DOIs
StatePublished - Dec 2012

Fingerprint

Autophagy
Homeostasis
Antigen Presentation
Recycling
Adaptive Immunity
Innate Immunity
Proteolysis
Immune System
Proteins
T-Lymphocytes
Amino Acids

Keywords

  • Antigen presentation
  • Autophagy
  • Dendritic cell
  • Macrophage
  • Pathogen
  • T cell

ASJC Scopus subject areas

  • Pharmacology

Cite this

Autophagy and the regulation of the immune response. / Valdor, Rut; Macian-Juan, Fernando.

In: Pharmacological Research, Vol. 66, No. 6, 12.2012, p. 475-483.

Research output: Contribution to journalArticle

@article{a290ba2f5b6b4a4e9be371902c1d9a30,
title = "Autophagy and the regulation of the immune response",
abstract = "Autophagy is a highly conserved mechanism of lysosomal-mediated protein degradation that plays a crucial role in maintaining cellular homeostasis by recycling amino acids, reducing the amount of damaged proteins and regulating protein levels in response to extracellular signals. In the last few years specific functions for different forms of autophagy have been identified in many tissues and organs. In the Immune System, autophagy functions range from the elimination infectious agents and the modulation of the inflammatory response, to the selection of antigens for presentation and the regulation of T cell homeostasis and activation. Here, we review the recent advances that have allowed us to better understand why autophagy is a crucial process in the regulation of the innate and adaptive immune responses.",
keywords = "Antigen presentation, Autophagy, Dendritic cell, Macrophage, Pathogen, T cell",
author = "Rut Valdor and Fernando Macian-Juan",
year = "2012",
month = "12",
doi = "10.1016/j.phrs.2012.10.003",
language = "English (US)",
volume = "66",
pages = "475--483",
journal = "Pharmacological Research",
issn = "1043-6618",
publisher = "Academic Press Inc.",
number = "6",

}

TY - JOUR

T1 - Autophagy and the regulation of the immune response

AU - Valdor, Rut

AU - Macian-Juan, Fernando

PY - 2012/12

Y1 - 2012/12

N2 - Autophagy is a highly conserved mechanism of lysosomal-mediated protein degradation that plays a crucial role in maintaining cellular homeostasis by recycling amino acids, reducing the amount of damaged proteins and regulating protein levels in response to extracellular signals. In the last few years specific functions for different forms of autophagy have been identified in many tissues and organs. In the Immune System, autophagy functions range from the elimination infectious agents and the modulation of the inflammatory response, to the selection of antigens for presentation and the regulation of T cell homeostasis and activation. Here, we review the recent advances that have allowed us to better understand why autophagy is a crucial process in the regulation of the innate and adaptive immune responses.

AB - Autophagy is a highly conserved mechanism of lysosomal-mediated protein degradation that plays a crucial role in maintaining cellular homeostasis by recycling amino acids, reducing the amount of damaged proteins and regulating protein levels in response to extracellular signals. In the last few years specific functions for different forms of autophagy have been identified in many tissues and organs. In the Immune System, autophagy functions range from the elimination infectious agents and the modulation of the inflammatory response, to the selection of antigens for presentation and the regulation of T cell homeostasis and activation. Here, we review the recent advances that have allowed us to better understand why autophagy is a crucial process in the regulation of the innate and adaptive immune responses.

KW - Antigen presentation

KW - Autophagy

KW - Dendritic cell

KW - Macrophage

KW - Pathogen

KW - T cell

UR - http://www.scopus.com/inward/record.url?scp=84869508676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869508676&partnerID=8YFLogxK

U2 - 10.1016/j.phrs.2012.10.003

DO - 10.1016/j.phrs.2012.10.003

M3 - Article

VL - 66

SP - 475

EP - 483

JO - Pharmacological Research

JF - Pharmacological Research

SN - 1043-6618

IS - 6

ER -