Abstract
Just when you thought that you had heard it all about autophagy. -. the conserved cellular process that mediates turnover of cellular constituents in the lysosomes. -. studies keep coming out highlighting new types of autophagy, new functions for autophagy or even new autophagy-independent roles for the proteins associated with this process. The field of immunology has been riding the autophagic wave since the beginning of its revival; first due to its role in the host defense against pathogens, and more recently through the better understanding of the unique characteristics and functions of different autophagic pathways in immune cells. Here, we describe some of these new functions that are tightening the connection between autophagy and acquired or innate immunity and their malfunctioning with age.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 97-104 |
| Number of pages | 8 |
| Journal | Current Opinion in Immunology |
| Volume | 29 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2014 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Medicine(all)
Cite this
Autophagy and the immune function in aging. / Cuervo, Ana Maria; Macian-Juan, Fernando.
In: Current Opinion in Immunology, Vol. 29, No. 1, 2014, p. 97-104.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autophagy and the immune function in aging
AU - Cuervo, Ana Maria
AU - Macian-Juan, Fernando
PY - 2014
Y1 - 2014
N2 - Just when you thought that you had heard it all about autophagy. -. the conserved cellular process that mediates turnover of cellular constituents in the lysosomes. -. studies keep coming out highlighting new types of autophagy, new functions for autophagy or even new autophagy-independent roles for the proteins associated with this process. The field of immunology has been riding the autophagic wave since the beginning of its revival; first due to its role in the host defense against pathogens, and more recently through the better understanding of the unique characteristics and functions of different autophagic pathways in immune cells. Here, we describe some of these new functions that are tightening the connection between autophagy and acquired or innate immunity and their malfunctioning with age.
AB - Just when you thought that you had heard it all about autophagy. -. the conserved cellular process that mediates turnover of cellular constituents in the lysosomes. -. studies keep coming out highlighting new types of autophagy, new functions for autophagy or even new autophagy-independent roles for the proteins associated with this process. The field of immunology has been riding the autophagic wave since the beginning of its revival; first due to its role in the host defense against pathogens, and more recently through the better understanding of the unique characteristics and functions of different autophagic pathways in immune cells. Here, we describe some of these new functions that are tightening the connection between autophagy and acquired or innate immunity and their malfunctioning with age.
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UR - http://www.scopus.com/inward/citedby.url?scp=84902297732&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2014.05.006
DO - 10.1016/j.coi.2014.05.006
M3 - Article
VL - 29
SP - 97
EP - 104
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 1
ER -