@article{05d0f59c934a48c881d9e81565471c3a,
title = "Autophagy and the hallmarks of aging",
abstract = "Autophagy, an essential cellular process that mediates degradation of proteins and organelles in lysosomes, has been tightly linked to cellular quality control for its role as part of the proteostasis network. The current interest in identifying the cellular and molecular determinants of aging, has highlighted the important contribution of malfunctioning of autophagy with age to the loss of proteostasis that characterizes all old organisms. However, the diversity of cellular functions of the different types of autophagy and the often reciprocal interactions of autophagy with other determinants of aging, is placing autophagy at the center of the aging process. In this work, we summarize evidence for the contribution of autophagy to health- and lifespan and provide examples of the bidirectional interplay between autophagic pathways and several of the so-called hallmarks of aging. This central role of autophagy in aging, and the dependence on autophagy of many geroprotective interventions, has motivated a search for direct modulators of autophagy that could be used to slow aging and extend healthspan. Here, we review some of those ongoing therapeutic efforts and comment on the potential of targeting autophagy in aging.",
keywords = "Aging, Chaperones, Lysosomes, Organelle turnover, Proteolysis, Proteostasis",
author = "Susmita Kaushik and Inmaculada Tasset and Esperanza Arias and Olatz Pampliega and Esther Wong and Marta Martinez-Vicente and Cuervo, {Ana Maria}",
note = "Funding Information: Work in our laboratories is supported by the National Institutes of Health (USA) [AG054108, AG021904, AG017617, AG038072, AG031782 and NS100717 and DK098408 (to Ana Maria Cuervo) and P30AG038072 (P&F), P30DK041296 (P&F) and DK124308 (to Esperanza Arias)], Fondo de Investigaci?n Sanitaria-Instituto de Salud Carlos III (Spain)-FEDER [PI20/00728 (to Marta Martinez-Vicente), Spanish Ministry of Science and Innovation (Spain) [RTI2018?097948-A-100 and RYC-2016?20480 (to Olatz Pampliega)] and the generous support of the JPB Foundation (USA), the Rainwater Charitable Foundation (USA), the Glenn Foundation (USA), the Backus Foundation (USA), and of Robert and Renee Belfer (USA) (to Ana Maria Cuervo), the Grace Science Foundation (USA) (to Susmita Kaushik), the Michael J Fox Foundation (USA), the Silverstein Foundation (USA) and the BBVA Foundation (Spain). Funding Information: Work in our laboratories is supported by the National Institutes of Health (USA) [ AG054108 , AG021904 , AG017617 , AG038072 , AG031782 and NS100717 and DK098408 (to Ana Maria Cuervo) and P30AG038072 (P&F), P30DK041296 (P&F) and DK124308 (to Esperanza Arias)], Fondo de Investigaci{\'o}n Sanitaria-Instituto de Salud Carlos III (Spain)-FEDER [ PI20/00728 (to Marta Martinez-Vicente), Spanish Ministry of Science and Innovation (Spain) [ RTI2018–097948-A-100 and RYC-2016–20480 (to Olatz Pampliega)] and the generous support of the JPB Foundation (USA), the Rainwater Charitable Foundation (USA), the Glenn Foundation (USA), the Backus Foundation (USA), and of Robert and Renee Belfer (USA) (to Ana Maria Cuervo), the Grace Science Foundation (USA) (to Susmita Kaushik), the Michael J Fox Foundation (USA) , the Silverstein Foundation (USA) and the BBVA Foundation (Spain). Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",
year = "2021",
month = dec,
doi = "10.1016/j.arr.2021.101468",
language = "English (US)",
volume = "72",
journal = "Ageing Research Reviews",
issn = "1568-1637",
publisher = "Elsevier Ireland Ltd",
}