TY - JOUR
T1 - Autophagy and synaptic plasticity
T2 - epigenetic regulation
AU - Hwang, Jee Yeon
AU - Yan, Jingqi
AU - Zukin, Ruth Suzanne
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/12
Y1 - 2019/12
N2 - In neurons, autophagy is crucial to proper axon guidance, vesicular release, dendritic spine architecture, spine pruning and synaptic plasticity and, when dysregulated, is associated with brain disorders, including autism spectrum disorders, and neurodegenerative diseases such as Parkinson's and Alzheimer's disease. Once thought to play a housekeeping function of removing misfolded proteins or compromised organelles, neuronal autophagy is now regarded as a finely tuned, real time surveillance and clearance system crucial to synaptic integrity and function. Here we review the role of autophagy in synaptic plasticity and its regulation by epigenetic mechanisms.
AB - In neurons, autophagy is crucial to proper axon guidance, vesicular release, dendritic spine architecture, spine pruning and synaptic plasticity and, when dysregulated, is associated with brain disorders, including autism spectrum disorders, and neurodegenerative diseases such as Parkinson's and Alzheimer's disease. Once thought to play a housekeeping function of removing misfolded proteins or compromised organelles, neuronal autophagy is now regarded as a finely tuned, real time surveillance and clearance system crucial to synaptic integrity and function. Here we review the role of autophagy in synaptic plasticity and its regulation by epigenetic mechanisms.
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U2 - 10.1016/j.conb.2019.09.010
DO - 10.1016/j.conb.2019.09.010
M3 - Review article
C2 - 31634675
AN - SCOPUS:85073279566
SN - 0959-4388
VL - 59
SP - 207
EP - 212
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -