Autophagy and synaptic plasticity: epigenetic regulation

Research output: Contribution to journalReview article

Abstract

In neurons, autophagy is crucial to proper axon guidance, vesicular release, dendritic spine architecture, spine pruning and synaptic plasticity and, when dysregulated, is associated with brain disorders, including autism spectrum disorders, and neurodegenerative diseases such as Parkinson's and Alzheimer's disease. Once thought to play a housekeeping function of removing misfolded proteins or compromised organelles, neuronal autophagy is now regarded as a finely tuned, real time surveillance and clearance system crucial to synaptic integrity and function. Here we review the role of autophagy in synaptic plasticity and its regulation by epigenetic mechanisms.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalCurrent Opinion in Neurobiology
Volume59
DOIs
Publication statusPublished - Dec 2019

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ASJC Scopus subject areas

  • Neuroscience(all)

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