Autophagy and regulation of lipid metabolism

Rajat Singh

Research output: Chapter in Book/Report/Conference proceedingChapter

32 Citations (Scopus)

Abstract

Macroautophagy (henceforth referred to as autophagy) is an in-bulk lysosomal degradative pathway that plays a crucial role in the maintenance of cellular homeostasis through the removal of damaged proteins and aged organelles. Following nutrient deprivation, a primary cellular response is the induction of autophagy that breaks down redundant cellular components and provides amino acids and additional precursor molecules for processes critical for cellular survival. In parallel, nutrient depletion leads to the mobilization of cellular lipid stores to supply free fatty acids for energy, thus pointing to regulatory and functional similarities between autophagy and lipid metabolism. The current chapter discusses the novel and mutually exclusive roles of autophagy in the regulation of lipid metabolism in the liver and of fat storage within the adipose tissue. Our studies in cultured hepatocytes and the murine liver have demonstrated that autophagy serves to degrade intracellular lipid stores through a process that we have termed "macrolipophagy" and that ablation of liver-specific autophagy leads to excessive hepatic lipid accumulation and the development of fatty liver. In contrast, preadipocytes in culture that lacked autophagy failed to differentiate into mature adipocytes and exhibited a reduction in fat storage that translated to decreased adipose tissue mass in an in vivo mouse model. These recent findings establish an association between autophagy and regulation of hepatic lipid metabolism and adipose tissue biology, thus providing new mechanistic insights into the regulation of these complex processes. These findings also highlight the possibility of novel therapeutic approaches, such as differential organ-specific regulation of autophagy to solve problems that arise from lipid over accumulation that occur in the metabolic syndrome and with aging.

Original languageEnglish (US)
Title of host publicationResults and Problems in Cell Differentiation
Pages35-46
Number of pages12
Volume52
DOIs
StatePublished - 2010

Publication series

NameResults and Problems in Cell Differentiation
Volume52
ISSN (Print)00801844
ISSN (Electronic)18610412

Fingerprint

Autophagy
Lipid Metabolism
Liver
Adipose Tissue
Lipids
Fats
Lipid Mobilization
Food
Fatty Liver
Nonesterified Fatty Acids
Adipocytes
Organelles
Hepatocytes
Homeostasis
Maintenance
Amino Acids

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Singh, R. (2010). Autophagy and regulation of lipid metabolism. In Results and Problems in Cell Differentiation (Vol. 52, pp. 35-46). (Results and Problems in Cell Differentiation; Vol. 52). https://doi.org/10.1007/978-3-642-14426-4_4

Autophagy and regulation of lipid metabolism. / Singh, Rajat.

Results and Problems in Cell Differentiation. Vol. 52 2010. p. 35-46 (Results and Problems in Cell Differentiation; Vol. 52).

Research output: Chapter in Book/Report/Conference proceedingChapter

Singh, R 2010, Autophagy and regulation of lipid metabolism. in Results and Problems in Cell Differentiation. vol. 52, Results and Problems in Cell Differentiation, vol. 52, pp. 35-46. https://doi.org/10.1007/978-3-642-14426-4_4
Singh R. Autophagy and regulation of lipid metabolism. In Results and Problems in Cell Differentiation. Vol. 52. 2010. p. 35-46. (Results and Problems in Cell Differentiation). https://doi.org/10.1007/978-3-642-14426-4_4
Singh, Rajat. / Autophagy and regulation of lipid metabolism. Results and Problems in Cell Differentiation. Vol. 52 2010. pp. 35-46 (Results and Problems in Cell Differentiation).
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